GZMB KO后，CD8+ T细胞的活化水平上升。(b) FOXP3 KO增加滤泡辅助T细胞（TFH），GZMB KO影响更大GZMB KO导致TFH（CD38+PD1+CXCR5+CD4+）细胞大量增加。(c) FOXP3 KO和GZMB KO对B细胞的影响两者都导致浆母细胞（CD38++CD27++ B细胞）和生发中心B细胞（CD38+CD27+ B细胞）比例增加。逻辑 FOXP3 KO影响CD4+...
Flow cytometry detected CD4 + CXCR5 + PD1+ Tfh cells. Serum Bcl-6 and CXCL13 levels were determined using enzyme-linked immunosorbent assay. Results CD4 + CXCR5 + PD-1+ Tfh cell percentages in peripheral blood and serum levels of Bcl-6 and CXCL13 in the non-proliferative DR (NPDR) and...
Tfh 细胞的转录因子表达。来自鼠脾细胞 A) 通过淋巴细胞 (R1)、单细胞 (R2)、活细胞、非 B、CD3 + 细胞 (R3) 和 CD4 + 细胞 (R4)逐级设门,最后通过高水平的 CXCR5 和 PD1 共表达分出Tfh 细胞。B) 与初始 (TN CD44low/CXCR5low) CD4 T ...
SLE患者中CD4+CD28−T细胞、CD4+CXCR5−PD1+T细胞、CD8+HLADR+T细胞和CD8+CD38+HLADR+T细胞的比例增加,可能与疾病活动性和肾脏预后有关。这些T细胞的表型变化为疾病、SLE监测和治疗靶点的潜在生物标志物提供了线索,但是还需要进一步的大样本量的深入研究来验证这些表型变化在SLE的疾病监测和精确控制中的作用。
目的动态观测恩替卡韦治疗HBeAg阳性慢性乙型肝炎病毒携带者的临床疗效及其外周血PD-1 +CXCR5 +CD4 +T淋巴细胞、可溶性程序性死亡受体1(sPD-1)水平变化并探讨其临床意义。 方法慢性乙型肝炎病毒携带者治疗(A)组31例,慢性乙型肝炎患者治疗(B)组32例,慢性乙型肝炎病毒携带者未治疗(C)组15例,收集并比较3组患者0周...
在第 10-12 天,CD44hi PSGL1lo 多克隆 CD4 T 细胞的频率总体增加了 1.3 倍(KP-HELLO 与 KP),而这些进一步上调 PD-1 和 CXCR5 的 PSGL1lo 细胞的频率增加了 4 倍,导致 TFH 细胞频率显着增加。他们又将 KP-NINJA 或 KP-HELLO 肿瘤植入 Il4GFP 小鼠并分析 GP66 特异性 CD4 T 细胞的 TFH 标志物...
a,b, Statistical analysis of fold change in frequency of activated (CD27+CD38+) CD4+and CD8+T cells and TFH(CD38+PD1+CXCR5+CD4+) cells (a) and germinal center B cells and plasmablasts (b) in organoids withFOXP3KO orGZMBKO T cells compared with WT (n = 6 donors).c,d, Sta...
I组具有Th1细胞的特征,Ⅱ组为Tbx21和Ifng的低表达,表达趋化因子受体Cxcr3和转录因子Irf7。第三组表达典型的Treg细胞基因,包括Foxp3和Il2ra,编码CD25(IL-2Rα)。第四组表达Ccr7,在免疫反应早期优先标记记忆细胞前体,而第五组表达Tfh细胞...
(Bcl6+andCxcr5+)) and cluster 5 (Tregcell cluster (Foxp3+andCd25+)) in tumours from mice receiving either T3-HDVax or T3-LDVax compared with PBS. By contrast, the proportions of cells populating clusters 1–4, 6 and 8 were differentially affected by the MHC-II peptide dose used in ...
Figure 5. LAG-3+CXCR5+PD1+ CD4 T cells also expand in other chronic infections Mice were infected with LCMV Cl-13 intravenously and euthanized at various time points after infection. (A) Graph shows the frequency of LAG-3-expressing CD4 T cells over the course of infection. (B) Representa...