Here we report a CXCR5PD1 Tfh subset of CD8 T cells whose development and function are negatively modulated by Stat5. These CD8 Tfh cells regulate the germinal center B cell response and control autoantibody production, as deficiency of Stat5 in CD8 T cells leads to an increase of CD8 Tfh ...
不过有趣的是,大部分表达了PD-1的辅助性T细胞并不会同时表达CXCR5,但是会同时表达CD38和ICOS。 由于PD-1是一种共抑制受体(co-inhibitory receptor),作者们一开始怀疑这些CXCR5-PD1+细胞有可能已经由于长时间的感染而导致耗竭(exhausted)了。但是通过进一步地分析数据,作者们发现这些CXCR5-PD1+细胞不但有生产包括IFN-...
这项研究揭示了在被HIV感染的淋巴结中,滤泡辅助性T细胞会失去CXCR5的表达,这些CXCR5- T细胞依然有帮助B细胞的功能和重新表达CXCR5的能力,并且这些细胞还能够转移出淋巴结。该项工作通过对细胞蛋白质的表达的分析和共培养研究,详细解析了CXCR5-PD1+辅助性T细胞的功能。随后的测序证明了这种细胞有迁移的能力,并且和滤泡...
从低水平的HBV病毒血症患者中检测到的HBV特异性主要是PD1阳性CD8 + T细胞。同样,未患疾病发作的CHB患者血液中存在的HBV特异性CD8 + T细胞被选择性地富集到PD1 + T细胞群体中,这些细胞具有功能性。研究表明,PD1促进生发中心区域的滤泡辅助性T细胞浓度,表明PD1对细胞调节的作用更为复杂。 尽管我们的发现表明PD1负调节...
(4)免疫学指标:外周血PD1 +CXCR5 +CD4 +T淋巴细胞频率、血浆sPD-1浓度。(5)影像学指标:上腹部彩色多普勒超声或CT/MRI扫描,肝脏弹力检测。 4.检测方法:抽取患者清晨空腹外周静脉血5 ml,室温下肝素钠真空管抗凝。2 000 r/min( r=10 cm,下同)离心5 min,取上清液分装于EP管,置于-80 ℃冰箱冻存,用于酶...
suggesting potential recirculation into lymphoid tissue. These findings underscore the pivotal role of follicular CD8+ T cells in anti-HIV responses and support investigating targeted cure strategies, such as anti-PD1 therapy, especially in individuals initiating treatment during acute infection....
NETs促进肿瘤转移 最近,“Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL - 10” 的研究论文发表于Cancer Cell,揭示了中性粒细胞胞外陷阱(NETs)通过诱导网膜间皮细胞表达 CXCL13,招募表达IL-10的先天样B细胞,促进调节性T细...
Tfh cells (CD4+PD1+CXCR5+) can exhibit a tumor- supporting role in human B cell malignancies, foremost in FL and CLL18. To prove CXCR5 CAR reactivity against Tfh cells, we co-cultured CXCR5 CAR-T cells with sorted CD4+CXCR5+ T helper cells as a surrogate for intratumoral Tfh cells. ...
CD279/PDCD1/PD1 中和抗体-Mouse CD279/PDCD1/PD1 (Iv0010) VMH02201 CD28 CD28蛋白 CD282/TLR2 流式抗体:Mouse CD282/TLR2 Antibody (SAA1384) FMA95510 CD283/TLR3 流式抗体:Mouse CD283/TLR3 Antibody (132-E5) FMA53410 CD284/TLR4 流式抗体:Human CD284/TLR4 Antibody (SAA0095) FHA05310...
9566#Background:The phase II SWOG S1801 study showed an improved event-free survival with anti-PD-1 (PD1) neoadjuvant immunotherapy (neoIT) vs adjuvant PD1... IEDPD Silva,JW Conway,A Ramanathan,... - 《Journal of Clinical Oncology》 被引量: 0发表: 2024年 IMMU-38. DEEP IMMUNOPROFILING...