CD74占据MHCII的结合槽，防止内质网中内源性肽分子与MHCII结合。CD74的形成与跨膜区域和三聚体化结构域（C端细胞外区域中的氨基酸残基134-208）有关。CD74还参与MHCI呈递抗原，激活CD8+T细胞，引发MHCI介导的细胞毒性T细胞反应。此外，CD74还参与MIF信号传导，与CXCR2、CXCR4或CXCR7形成复合物，激活多条信号通路...
CD74基因调控CXCR4抑制肾癌786-O细胞的侵袭作用
CXCR4MIFChemokine receptorGPCRInvariant chainMIF is a chemokine-like inflammatory mediator that triggers leukocyte recruitment by binding to CXCR2 and CXCR4. MIF also interacts with CD74/invariant chain, a single-pass membrane-receptor. We identified complexes between CD74 and CXCR2 with a role ...
提示CD74在肺腺癌的发生发展中起重要作用。细胞外MIF是一种炎性细胞因子,与CD74、CXC趋化因子受体(CXCR)2、CXCR4和CXCR7相互作用,在许多肿瘤模型中诱导血管生成、增殖和间质-上皮转化。在肺Ⅱ型上皮细胞中,MIF与CD74结合,与细胞增殖...
Recent studies have identified CXCR2 and CXCR4 as co-receptors for CD74 where MIF binding to CD74 complexes contributes to MIF-mediated monocyte chemotaxis and the induction of Akt signaling, respectively (7,8). Increased CD74 surface expression has been re...
Gene expression analyses using microarray and RT - qPCR technology revealed a 4-fold upregulation of several interferon-induced genes upon co-treatment of myofibroblasts with sCD 74 and MIF (Ifi44: P=0.011; Irg1: P=0.022; Clec4e: P=0.011). Furthermore, Western blot analysis confirmed the ...
[11]. Antibody blockade experiments revealed that atherogenicleukocyte recruitmentby MIF is dependent on CD74. An overlap between the MIF/CD74 and MIF/CXCR2 or MIF/CXCR4 signaling pathways has been suggested[11]. InT cells, both CD74 andCXCR4were required for MIF-stimulated AKT signaling, ...
Fig. 4. CD74 as a receptor for the cytokines macrophage migration inhibitory factor (MIF) and MIF-2. MIF and MIF-2 bind to the extracellular domain of CD74. In order to induce signalling, CD74 requires co-receptors like CD44 or CXCR4. Activation of several downstream signalling pathways ...
However, the contribution of MIF or MIF-2 to these actions of MIF receptors has not been explored. The safety and efficacy of strategies targeting MIF, CD74, CD44 and CXCR4 are under study in humans. 展开 关键词: Kidney CD74 CXCR2 CXCR4 Macrophage inhibitory factor ...
1表达和THP-1黏附EA.hy926受到抑制;重组MIF可以逆转ISO-1的这种抑制作用.阻断MIF的受体CD74和CXCR4后,ICAM-1蛋白和m RNA表达减少,THP-1与EA.hy926的结合受到... 徐婉悦,张冬梅,徐秋芳,... - 全国牙周病学学术会议 被引量: 0发表: 0年 加载更多来源...