Repeated antigen-driven proliferations cause CD28 on T cells to down-regulate. We hypothesized that alloantigen-induced proliferations could cause CD28 down-regulation in lung transplant recipients. To ascertain if CD28 down-regulation on CD4 T cells associated with manifestations of allograft dysfunction...
Fig3. Expression characterization of hCD28 on CD4+ and CD8+ T cells in blood in homozygous hCD28 KI mice. Fig4. Cytokine release post stimulation with anti-CD28 antibodiesin vitro. 相关品系 hCD28/hPSMA 品系名:C57BL/6Smoc-Cd28em2(hCD28)Folh1em1(hPSMA-Wpre-PA)Smoc ...
《现代免疫学))2006年第26卷第4期 CD4+CD28一T淋巴细胞与自身免疫性疾病 孙治平 综述 张学光 审阅 (苏州大学生物技术研究所,苏州 215007) 摘要:CD4CD28T细胞是一个具有特殊生物学效应的细胞亚群,高频出现于某些自身免疫性疾病中,具有细胞毒样的 侵蚀特性、T细胞活化的不平衡性及抗凋亡特征,与疾病的发生、发展及...
Increased PD-1 on CD4+CD28− T cell and soluble PD-1 ligand-1 in patients with T2DM: Association with atherosclerotic macrovascular diseases Increased PD-1 on CD4 + CD28 - T cell and soluble PD-1 ligand-1 in patients with T2DM: association with atherosclerotic macrovascular diseases[J]. ....
目的:探讨共刺激分子在桥本甲状腺炎(HT)发病中的免疫病理作用.方法:采用免疫组织化学法检测20例HT和20例甲状腺瘤旁正常组织(对照组)CD40/CD40L,B7-1/CD28,GL50,CD4和C... 殷洪二,郦文琴,陈蕾,... - 《交通医学》 被引量: 0发表: 2005年 B7.1 Costimulatory Molecule Is Expressed on Thyroid Follicular Ce...
The goal of this study was to determine whether these genes are overexpressed on the same or different T cells and whether this subset of CD4+ T cells is also present in patients with lupus and other rheumatic diseases. 展开 关键词: Systemic...
CD4+CD28null T lymphocytes resemble CD8+CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients Larrea C, Alonso-Arias R: CD4+CD28null T lymphocytes resemble CD8+CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected ... A Echeverría...
第一部分急性冠状动脉综合征患者CD4 + 、CD4 + CD28 null T细胞 Kv1.3钾通道的表达及意义 【目的】研究急性冠状动脉综合征(acutecoronarysyndrome,ACS)患者外周血中 CD4 + T细胞及其亚型CD4 + CD28 null T细胞活化前后Kv1.3钾通道数目的变化以及Kv1.3钾通道阻滞剂对CD4 + T细胞活化表达的影响,探讨Kv1.3钾通道在...
调节性T细胞是一类表型和功能特异的T细胞亚群,其中CD4+CD25+调节性T细胞是近年来被研究得较为深入的一个亚类,也最值得引起人们的关注.虽然有研究已经证实CD4+CD25+调节性T细胞能够抑制CD4+CD25-T细胞和CD8+T细胞的活化和增殖,但其具体的作用机制还不清楚,有研究表明CD28/CTLA-4对CD4+CD25+调节性T细胞的产生,维持和...
CD4+PD-1+、CD8+PD-1+表达与急性生理学和慢性健康评估系统(APACHE Ⅱ)、序贯器官衰竭(Sequential Organ Failure Assessment,SOFA)评分呈正相关。 (2)评估脓毒症患者T淋巴细胞耗竭及免疫抑制状态水平 PD-1表达水平升高代表T淋巴细胞耗竭及免疫抑制状态水平升高。