T细胞亚群共刺激分子免疫状态乙型肝炎患者HBeAg阳性HBeAg阴性外周血慢性HBV携带者从免疫状态的角度探讨CD8+CIM5RA+CD28一T细胞亚群(简称CD28+T细胞)和第二信号共刺激分子CD8+CD28+(简称CD28+),CD8+CD152+(简称CD152+)的表达变化.根据慢性乙型肝炎防治指南,选取不同免疫状态的慢性HBV携带者,HBeAg阳性慢性乙肝患者,HBeA...
从免疫状态的角度探讨CD8+CIM5RA+CD28一T细胞亚群(简称CD28+T细胞)和第二信号共刺激分子CD8+CD28+(简称CD28+),CD8+CD152+(简称CD152+)的表达变化.根据慢性乙型肝炎防治指南,选取不同免疫状态的慢性HBV携带者,HBeAg阳性慢性乙肝患者,HBeAg阴性慢性乙肝患者各40例.对照组40例:自述无肝炎史,肝功能正常;HBsAg,anti....
In response to antigen naive CD8+, T cells differentiate into effector cells, which express Natural killer (NK) receptors, lose CD28 expression, and die by apoptosis. However, in smaller quantities, the cells are retained for subsequent exposure to the s
Patients with both CD8 and PD1 genes expression above the 25th percentile were considered as CD8+PD1+ cohort and, subsequently, stratified in two groups, CD28+ and CD28−, based on CD28 gene expression levels, considering the 25th percentile as cutoff. Survival analysis Survival analysis for ...
Antiretroviral therapy corrects HIV-1-induced expansion of CD8+ CD45RA+ CD2-) CD11a(bright) activated T cells. HIV infection decreases thymic output and induces chronic T-cell activation. To examine the reconstitution of naive and activated T cells. Extended immune ... L Yin,CA Rodriguez,W ...
In HIV-1-infected individuals, the CD8+ CD28− T cell subset is considerably expanded and is frequently the largest subset of T cells found in peripheral blood. It has been assumed, but not proven, that CD8+ CD28− T cells derive from CD8+ CD28+ T cells in vivo. To further...
The leukocyte common antigen isoforms CD45RA and CD45RO have long been used to discriminate human naive and memory T cells respectively. This model was largely based on the observation that CD45RO+ T cells respond preferentially to and show a higher frequency of precursors specific for recall ...
An age-dependent decrease in T cell responsiveness to CD28 costimulation has been described. In order to test the hypothesis that an age-related decrease in CD28 expression by CD8+ T lymphocytes might be involved, we analysed 67 healthy donors ranging in age from 15 to 69 years for their CD8...
Macrophage infection by HIV-1: focus on viral reservoirs and pathogenesis The case of a 29-year-old Caucasian woman with 45 X0 karyotype, known as Turner's syndrome, and a recently diagnosed selective T-cell deficiency is reporte... LJ Montaner,CF Perno,Crowe SM - 《Journal of Leukocyte ...
Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro. The ability of HIV-1 to establish an infection and replicate to high copy number in CD4 lymphocytes is dependent on both the activation state of the cell a... CA Spina,HE Prince,DD Ri...