et al. Cutting Edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice. J. Immunol. 169, 3475–3479 (2002). CAS PubMed Google Scholar Karin, M....
基于独具技术优势的哺乳动物细胞表达平台,我司自主研制的GMP级CD3(货号:GMP-TL101)、CD28(货号:GMP-TL102)、CD16(货号:GMP-TL201)等单克隆抗体,均有正确的翻译后修饰(例如,二硫键、糖基化及磷酸化等),与天然抗体类似性高、活性强、效果好、稳定性高。同时,我司可按客户需要对抗体的相关基因进行突变或重组改...
Additional criteria for the selection of tag-SNPs was based on published scientific reports to demonstrate their potential role in autoimmunity or inflammatory diseases in CD2819,20 and NFKB1 gene region.22,30 Conse- quently, in this study we selected three-tag SNPs in the gene regions of ...
CD28 is a 44-kDa disulfide-linked glycoprotein expressed constitutively in the majority of CD4+ and CD8+ T cells. It binds to CD80 (B7.1) and CD86 (B7.2), expressed on the surface of APCs. The interaction of CD28 with its ligands promotes T-cell proliferation, IL-2 production, and surv...
CD8+ CD28- and CD8+ CD57+ T cells and their role in health and disease. Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8+ T-c... M Strioga,V Pasukoniene,D Characiejus - 《Immunology》 被...
Lymphocyte purity was evaluated on PBMC by the expression CD45 (Table S2) and was > 99%. The rationale for this approach was to avoid the potential interference of flow cytometry mAbs with Rhapsody mAbs, according to guidelines provided by the manufacturer. Approximately 35.000 to 350.000 ...
IL‐15 augmented the cytotoxic properties of CD4+CD28null T cells by increasing both the mRNA transcription and storage of granzyme B and perforin for the cytolytic effector functions. Moreover, pretreatment of CD4+CD28null T cells with IL‐15 displayed a synergistic effect on the IFN‐γ ...
B、KD39与CD40 C、CD2与LFA-3 D、CD4-MHC-Ⅱ E、CD8-MHC-Ⅱ 热门试题 单项选择题 以下哪种分子不存在T细胞表面 A、CD2 B、CD3 C、CD28 D、TCR E、CD80 单项选择题 MΦ不表达 A、C3b受体 B、细胞因子受体 C、IgGFc受体 D、MHCˉⅡ分子
In FIG. 4, the cytokine IL-4 on a protein and simultaneously on a single-cell level is proven by flow-cytophotometric analysis. For this purpose, the cells are firstly stained with mAk against the surface molecule CD4, then fixed and made permeable, with the result that the IL-4 protein...
Memory HIV-specific precursor cytotoxic T lymphocytes are found in both CD28 positive and CD28-CD8+ cells, however, a CD28-CD57- subpopulation had fewer. Because CD28-CD57+ cells are antigen-driven with limited diversity, the loss of CD28 on CD8 T cells during disease progression may reduce ...