Repeated antigen-driven proliferations cause CD28 on T cells to down-regulate. We hypothesized that alloantigen-induced proliferations could cause CD28 down-regulation in lung transplant recipients. To ascertain if CD28 down-regulation on CD4 T cells associated with manifestations of allograft dysfunction...
Fig1. Expression characterization of hCD28 on T cells in blood in heterozygous hCD28 KI mice. Fig2. Expression characterization of hCD28 on CD4+ and CD8+ T cells in blood in heterozygous hCD28 KI mice. Fig3. Expression characterization of hCD28 on CD4+ and CD8+ T cells in blood in...
Giampaolo N,Rosanna A,Antonio L,et al.CD4+CD28 null T lymphocytes are expanded in young women with polycystic ovary syndrome[J].Fertil Steril,2011,95(8):2651-2654.Niccoli G,Apa R,Lanzone A. CD4+ CD28 null T lymphocytes are expanded in young women with polycystic ovary syndrome[J]....
《现代免疫学))2006年第26卷第4期 CD4+CD28一T淋巴细胞与自身免疫性疾病 孙治平 综述 张学光 审阅 (苏州大学生物技术研究所,苏州 215007) 摘要:CD4CD28T细胞是一个具有特殊生物学效应的细胞亚群,高频出现于某些自身免疫性疾病中,具有细胞毒样的 侵蚀特性、T细胞活化的不平衡性及抗凋亡特征,与疾病的发生、发展及...
Increased PD-1 on CD4+CD28− T cell and soluble PD-1 ligand-1 in patients with T2DM: Association with atherosclerotic macrovascular diseases Shi BM; Du X; Wang Q;.Increased PD-1 on CD4+ CD28-T cell and soluble PD-1 ligand-1 in patients with T2DM: association with atherosclerotic ......
CD4+CD28-T细胞与糖尿病 万方数据
Autoreactive CD4+ CD28 来自 ProQuest 喜欢 0 阅读量: 13 作者: Behnam Zal,Christina Baboonian,Juan Carlos Kaski 摘要: Comment on Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2421-32.关键词:alpha(IIb)beta(3 GPIIb/IIIa alpha(IIb)beta(3 antagonists integrin antiplatelet therapy ...
而CD4^+CD28^-和CD8+CD28^-则表达增加;血清中IFN-γ及hs-CRP水平明显高于对照组;以上差别均有统计学意义(P〈0.05).且HT患者CD4^+CD28^-和CD8+CD28^-表达比例分别与血清中IFN-γ和hs-CRP水平呈正相关(r=0.383,P=0.006;r=0.309,P=0.029).结论:HT存在免疫调节功能异常,CD4^+和CD8+T淋巴细胞表面的CD28的...
调节性T细胞是一类表型和功能特异的T细胞亚群,其中CD4+CD25+调节性T细胞是近年来被研究得较为深入的一个亚类,也最值得引起人们的关注.虽然有研究已经证实CD4+CD25+调节性T细胞能够抑制CD4+CD25-T细胞和CD8+T细胞的活化和增殖,但其具体的作用机制还不清楚,有研究表明CD28/CTLA-4对CD4+CD25+调节性T细胞的产生,维持和...
第一部分急性冠状动脉综合征患者CD4 + 、CD4 + CD28 null T细胞 Kv1.3钾通道的表达及意义 【目的】研究急性冠状动脉综合征(acutecoronarysyndrome,ACS)患者外周血中 CD4 + T细胞及其亚型CD4 + CD28 null T细胞活化前后Kv1.3钾通道数目的变化以及Kv1.3钾通道阻滞剂对CD4 + T细胞活化表达的影响,探讨Kv1.3钾通道在...