(regulatoryT cell,Treg)作为目前发现的抑制性T细胞,越来越受到肿瘤免疫学的重视.本研究通过观察肺癌患者外周血中CD8+CD28+T细胞,CD8+CD28-T细胞及CD4+CD25highCD127lowTreg的表达水平,并对CD8+CD28-T细胞和CD4+CD25highCD127lowTreg细胞的表达情况行相关性分析,探讨负性免疫调节性T细胞在肺癌免疫中的作用及临床意义....
CD127 im- munophenotyping suggests altered CD4+ T cell re- gulation in primary progressive multiple sclerosis. J Autoimmun 2008;31:52-58.McKay, F.C.; Swain, L.I.; Schibeci, S.D.; Rubio, J.P.; Kilpatrick, T.J.; Heard, R.N.; Stewart, G.J.; Booth, D.R. CD127 ...
The CD4+CD28null and the regulatory CD4+CD25High T-cell phenotypes in patients with ulcerative colitis during active and quiescent disease, and following c... The CD4+CD25High T-cell phenotype has an essential immunoregulatory role, while the CD4+CD28null T-cell reflects immune pathology. We in...
CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 ...
Materials and methods We characterized the distinct T-cell phenotypes based on the expression of costimulatory molecules CD28 and CD27, senescence markers PD-1 and CD57, chronic immune activation markers CD38 and HLA-DR, and survival marker CD127 (IL-7R) by flow cytometry following activation of...
CD4+CD25highCD127low/− Tregs isolated from URSA patients and normal controls were hyporesponsive to anti-CD3/CD28 bead stimulation (2.3 ± 0.3% versus 1.9 ± 0.4%, P > 0.05), indicating that CD4+CD25highCD127low/− T cells from URSA patients exhibited appropriate anergy....
cDl27-PE、cD4一PE—cy5单抗;,J、鼠抗人cD28-兀Tc、cDB—PE单 抗;小鼠抗人cD,-唧、cD,。一PE单抗。每管加100¨l抗凝 全血后混匀避光孵育30血n,溶血后磷酸盐缓冲液洗2次, 作者单位:325000温州医学院附属第一医院医学科学研究所 短篇论著 流式细胞仪分析其外周血中cDfcD毒cDl"Ⅳ一Thg、cTL、NK ...
S1710 The Significance of Monitoring Peripheral CD4+ T-Cells Expressing Regulatory CD25High+ and the Immune-Deficiency CD4+ T-Cells Lacking CD28 in Patient... W1230 CD4+Cd25highfoxp3+ T-Regulatory Cells in Crohn's Disease Patients Treated with Infliximab - Gastroenterology K Kamikozuru,K Fukunaga...
结论在EBV感染儿童IM发病过程中,CD4CD25ghCD127的降低可能对EBV转化的“永生细胞”在体内的有效抑制起着主要的作用。【关键词】EB病毒;传染性单核细胞增多症;CD19CD23;CD4CD25ghCD127StudyoftheinhibitionefectsofCD4CD25“CD127ontheimmortalizedcellsinchildren、vithinfectiOUSmononucleosisQIULian—n,Z肋y0n一Z,LO...
CTLA-4 (Cytotoxic T Lymphocyte-associated Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T-cells. Its extracellular domain has a variable domain-like Ig fold. Loops corresponding to CDRs of antibodies can be substituted with heterologous sequence to confer different binding propertie...