Multiple sclerosis (MS) is an immune-mediated disease in which autoimmune T conventional (Tconv) cells break the blood–brain barrier and destroy neurons of the central nervous system. It is hypothesized that CD4+CD25highCD127−FoxP3+T regulatory (Treg) cells may inhibit this destruction throu...
Preactivated CD4+ CD25high Treg had no effect on the maturation of pDC. Conversely, they strongly suppressed TLR-triggered mDC costimulatory molecules up-regulation, pro-inflammatory cytokines secretion and their antigen presentation capacity, as opposed to conventionnal T cells (Tconv). At a ratio...
Although unfractionated CD4+ T cells have not been shown to be an efficient facilitating population, CD4+CD25+ regulatory cells (T-reg's) were examined for their capacity to support allogeneic hematopoietic engraftment. In a murine fully major histocompatibility complex (MHC)-mismatched BMT model, ...
IL-7 induced CIM CD25 regulatory T cells exerted weaker suppressor activity than natural regu latory T cells.Only IL-7 (4 ri g/m1) and IL-2 (2 000 U/m1) induced CD4 CD25 regulatory T cells showed the strongest killing activity.Conclusion :We successfully expand ...
选方法,并且扩增倍数高、可持续高表达CD4及CD25细胞表型。 [关键词] 白介素7;脐血;CD4CD25T细胞;调节性T细胞 EfectsofIL-7andIL-2onCD4CD25一Tcellsproliferationinvitro ZHANGJie,HAOJing—Sheng,LIJun-Fu,XINGL0ng—L0ng,LIUz-Wen,ZHONGLi,LIUWet.CollegeofLife ...
T cellsthymustoleranceThe main function of regulatory T lymphocytes is to keep autoimmune responses at bay. Accordingly, it has been firmly established that the repertoire of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) is enriched in autospecific cells. Differences in thymic-positive and/...
We also analyzed the ratio of Tregs to conventional T cells (Tconv) by dividing the CD4+CD25hiFOXP3+ frequency by the CD4+CD25−FOXP3− frequency. Tconv frequencies were similar in the 2 groups (11.8 ± 0.97 versus 10.5 ± 0.91). The mean Treg/Tconv ratio was significantly lower ...
Studies on CD4+CD25+ regulatory T cells (Tregs) with transgenic T-cell receptors indicate that Tregs may receive continuous antigen (Ag) stimulation in the periphery. However, the consequence of this Ag encounter and its relevance to physiologic polyclonal Treg function are not established. In auto...
transgenic FVB/N (H-2q) mice were co-transplanted into lethally-irradiated (800cGy) Balb/c (H-2d) host along with 5x106 wild-type FVB/N T-cell depleted bone marrow (TCD-BM) cells and 2x106 whole splenocytes, the latter containing approximately 30% T cells (Tconv) which induce ...