2023年8月8日，信达生物在Nature Cancer期刊发表了题为“IL-2Rα-biased agonist enhances antitumor immunity by invigorating tumor-infiltrating CD25+CD8+ T cells”文章 [1]。该报道揭示了抗PD-1/IL-2双特异性抗体融合蛋白（IBI363）的早期临床前核心机制研究结果。数年来，随着对T细胞亚群的不断研究，一群...
参考资料:1#Scientists develop next-generation immunotherapy now entering early phase clinical trials(来源:Cancer Research UK)2#Isabelle Solomon et al. CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity. Nature Cancer(2020)....
2#Isabelle Solomon et al. CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation andantitumorimmunity. Nature Cancer(2020).
而作为一个具有独立免疫调节功 能的 T 细胞亚群,调节性 T 细胞 (regulatory T cells,Treg细胞)由Sakaguchi等[1]在对啮齿类动物 的研究中首次发现,其免疫学特性主要表现在抑制 自身反应性 T 细胞的活化,参与机体免疫耐受,在 正常妊娠过程中扮...
Cells, CulturedAstragalus membranaceusCyclosporinePlant PreparationsImmunosuppressive AgentsRadioimmunoassayIntroductionRecently it has been reported that CD25 regulatory T cells (Treg) down-regulate immune responses. The aim of our study was to investigate the effects of AMI on allograft survival and its ...
CD25又名白介素(IL)- 2受体-α-亚基(IL-2Rα),其在调节性T细胞(Regulatory T cells,Treg细胞)中高表达;Treg细胞对多种免疫细胞起到抑制作用,同时也是多数实体瘤预后不良的重要因素。因此,消除肿瘤微环境中的Treg细胞成为抗肿瘤免疫的重要策略之一。
"Regulatory T Cells (Tregs) and COVID-19: Unveiling the Mechanisms, and Therapeutic Potentialities with a Special Focus on Long COVID." Vaccines 11.3 (2023): 699.[3] Sakaguchi, Shimon, et al. "Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains ...
包装规格:1×10cells/T25培养瓶 是否是肿瘤细胞:否 是否进口:否 商品介绍: 名称PC-61 (小鼠杂交瘤细胞CD25) 别称PC 61 5.3; PC 61.5.3; PC615.3; PC 61 生长特性 悬浮细胞 生物安全等级 1 生长培养基 DMEM+0.05mM β-mercaptoethanol+10% FBS+1% P/S ...
“[4“]KhazaieK,VonBoehmerH.TheimpactofCD4+CD25+TregontumorspecificCD8+Tcellcytotoxicityandcancer“[J“].SeminCancerBiol,2006,16(2):124136. “[5“]LimHW,HillsamerP,BanhamAH,etal.Cuttingedge:DirectsuppressionofBcellsbyCD4+CD25+regulatoryTcells“[J“].JImmunol,2005,175(7):41804183. “[6“...
CD25又名白介素-2受体α亚基(IL-2Rα),其在调节性T细胞(Regulatory T cells,Treg细胞)中高表达,是靶向Treg细胞的潜在靶点。由于Treg细胞对多种免疫细胞起到抑制作用,同时也是多数实体瘤预后不良的重要因素,因此消除肿瘤微环境中的Treg细胞成为抗肿瘤免疫治疗的重要策略之一。