McElwee KJ, Freyschmidt-Paul P, Hoffmann R, Kissling S, Hummel S, Vitacolonna M, Zoller M (2005) Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse...
The number of CD4+CD25+CD127loFoxp3+cells in MS was not significantly different to HD (p = 0.472, Fig.1Bc). However, the spread of counts was wider in MS patients as a proportion of MS patients had either low or higher absolute numbers. There was no difference between HD and MS...
An essential role for Scurfin in CD4+CD25+ T regulatory cells Here we show that Foxp3 is highly expressed by TR cells and is associated with TR cell activity and phenotype. Scurfin-deficient mice lack TR cells, ... R Khattri,T Cox,SA Yasayko,... - 《Nature Immunology》 被引量: 602...
Naturally arising CD25+ CD4+ regulatory T cells (TR) play an important role in the prevention of autoimmunity. TCR specificity is thought to play a critical role in TR development and function, but the repertoire and specificity of TR TCRs remain largely unknown. We find by sequencing of TRAV...
When autologous CD25− PBMC fractions were incubated with tumor cells from patients (n = 6) in vitro, there was consistent strong induction and then expansion of cells with the CD4+CD25+FoxP3+ phenotype of classic “natural” Treg cells. This population was confirmed to be suppressive in ...
Aβ-Teffs affect Treg frequency and function.aFrequency of CD4+CD25+FOXP3+ Tregs in blood, spleen and lymph nodes fromn = 6 mice per group. Statistical differences were determined using one-way ANOVA followed by Newman–Keuls post hoc test. *p < 0.05, **p < 0.01, ***p...
目的探讨多发性骨髓瘤(MM)患者外周血CD4+CD25highCD127low/-调节性T(Tregs)细胞表达水平及临床意义。方法采用流式细胞术(FCM)检测30例MM患者和20例健康对照者外周静脉血CD4+CD25highCD127low/-Tregs细胞水平。结果 1 MM组CD4+CD25high CD127low/-Tregs细胞表达明显高于正常对照组(P<0.05)。2MM组不同国际分期系...
CD4+ T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8+ cytotoxic T lymphocyte (CTL) anticancer responses, as proven in mouse models. We recently identified cDC1s with a transcriptomic imprint of CD4+ T-cell help
目的:观察肝癌患者手术治疗前后CD4+CD25+Tregs的变化。探讨 手术治疗与患者免疫之间的关联性及意义。 方法:收集2010年12月.2011年12月在衡水市哈励逊医院住院的肝 细胞肝癌患者,男15例,女5例;正常对照组20例,来自衡水市哈励逊 健康体检者。 入组标准:l、肿瘤单发<5cm,或病灶小于3个,每个病灶均<3cm。
Cell suspensions were centrifuged and stained with the following with antibodies at 0.5 µg ml−1 per antibody: APC anti-mouse CD3, Pacific Blue anti-mouse CD4, BV785 anti-mouse CD8, PerCP anti-mouse CD25, FITC anti-mouse F4/80, Pe-Cy7 anti-mouse CD11c, PE anti-mouse NK1.1...