McElwee KJ, Freyschmidt-Paul P, Hoffmann R, Kissling S, Hummel S, Vitacolonna M, Zoller M (2005) Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse...
Naturally arising CD25+ CD4+ regulatory T cells (TR) play an important role in the prevention of autoimmunity. TCR specificity is thought to play a critical role in TR development and function, but the repertoire and specificity of TR TCRs remain largely unknown. We find by sequencing of TRAV...
目的探讨多发性骨髓瘤(MM)患者外周血CD4+CD25highCD127low/-调节性T(Tregs)细胞表达水平及临床意义。方法采用流式细胞术(FCM)检测30例MM患者和20例健康对照者外周静脉血CD4+CD25highCD127low/-Tregs细胞水平。结果 1 MM组CD4+CD25high CD127low/-Tregs细胞表达明显高于正常对照组(P<0.05)。2MM组不同国际分期系...
IL-10 from CD4+CD25−Foxp3−CD127− Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effectiv... ...
(CD25) and IL-2Rβ (CD122) in Aiolos-deficient cells, whileIl6st(encoding the IL-6R subunit gp130) was decreased (Fig.2a, b box IV). This was notable, as IL-2/STAT5 signaling is known to not only antagonize TFHdifferentiation, but also induce the expression of numerous genes ...
When autologous CD25− PBMC fractions were incubated with tumor cells from patients (n = 6) in vitro, there was consistent strong induction and then expansion of cells with the CD4+CD25+FoxP3+ phenotype of classic “natural” Treg cells. This population was confirmed to be suppressive in ...
河北医科大学 硕士学位论文 肝癌患者手术治疗前后CD4+CD25+Tregs的变化及意义 姓名:*** 申请学位级别:硕士 专业:外科学 指导教师:**利 201203 中文摘要 肝癌患者手术治疗前后CD4+CD25+Tregs的变化及意义 摘要 目的:观察肝癌患者手术治疗前后CD4+CD25+Tregs的变化。探讨 手术治疗与患者免疫之间的关联性及意义。 方法...
An essential role for Scurfin in CD4+CD25+ T regulatory cells Here we show that Foxp3 is highly expressed by TR cells and is associated with TR cell activity and phenotype. Scurfin-deficient mice lack TR cells, ... R Khattri,T Cox,SA Yasayko,... - 《Nature Immunology》 被引量: 602...
CD4+ T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8+ cytotoxic T lymphocyte (CTL) anticancer responses, as proven in mouse models. We recently identified cDC1s with a transcriptomic imprint of CD4+ T-cell help
Resting and activated subpopulations of CD4+CD25+CD127loT regulatory cells (Treg) and CD4+CD25+CD127+ effector T cells in MS patients and in healthy individuals were compared. Peripheral blood mononuclear cells isolated using Ficoll Hypaque were stained