In a pilot study of juvenile myelomonocytic leukemia cases, we noted that CD14++/CD16 monocyte fraction was >95% in de novo juvenile myelomonocytic leukemia (JMML) with somatic PTPN11 mutations but normal in those with monosomy 7 or Noonan syndrome. Monocyte subgroup profiling by itself is not ...
whereas the difference in CD14++CD16− monocyte counts did not reach statistical significance (CD14++CD16− cells: HD 455±235 cells μl−1, PD 376±126 cells μl−1, P=0.165; CD14++CD16+ cells: HD 57±34 cells μl−1, PD 37±22 cells μl−1, P=0.006; CD14+CD16+ ...
目的采用孟德尔随机化(MR)分析探究表达程序性死亡受体配体1(PD-L1)的CD14 ++CD16 +单核细胞与急性呼吸窘迫综合征(ARDS)之间的因果关系。 方法以表达PD-L1的CD14 ++CD16 +单核细胞为暴露因素,以ARDS为结局因素。通过全基因组关联分析数据库获取单核苷酸多态性(SNP)作为工具变量。表达PD-L1的CD14 ++CD16 +单...
The frequency of CD14+ monocytes was significantly decreased, while the CD14+CD16+ monocyte population was significantly expanded during ZIKV infection compared to uninfected controls. Viral RNA was detected in PBMCs from all patients, but in serum from only a subset, suggesting PBMCs may be a ...
The CD14 monocyte subset expresses a component of the lipopolysaccharide (LPS) receptor complex, are large with diameter of ~18 μm, represent ~80%–90% of circulating monocytes, and express higher levels of CD62L (L-selectin) and CD11b (also referred to as Mac-1 or CR3) and lower ...
CD14+CD16+单核细胞是一群独特的单核细胞。这群 细胞与经典的单核细胞比较,其细胞表面分子有不同的特征。在人类,经典的CD14++CD16-单核细胞表达 CCR2,CD64,CD62L,CD14+CD16+单核细胞则不表达 G1 ++ - theclassicalmonocyte lackingdistinctorindividual ...
Akadeum’s Human Monocyte Isolation Kit for the enrichment of untouched CD14+ monocytes. This kit can process up to 1 billion MNCs. Complete in ~30 minutes
已知的主要根据 CD14和 CD16 抗原的表达分为 4 个亚型: CD14 ++ CD16 -( G1亚型), CD14 ++ CD16 + ( G2 亚型), CD14 + CD16 -( G3 亚型), CD14 + CD16 + ( G4 亚型)。其中最主要的有 2 型,其一我们已知的 CD14 强阳性的 ( CD14 ++ CD16 - 单核细胞) 经典的单核细胞外, 另一型...
ΠCD16 + 表达水平随病情好转而逐渐降低, 病情危重时则持续高表达。结论:新生儿血中单核细胞CD14 + ΠCD16 + 表达水平仅在败血症时显著增高,并随病情而变化,因 此,它可能对败血症具有诊断意义,与败血症的预后有一定联系。 关键词 败血症 新生儿 流式细胞术 单核细胞 ...
Monocytes are key players in atherosclerotic. Human monocytes display a considerable heterogeneity and at least three subsets can be distinguished. While the role of monocyte subset heterogeneity has already been well investigated in coronary artery dise