(B-cell, 49; T-cell, 8; Hodgkin lymphoma, 19), 1 Langerhans cell histiocytosis, and 14 nonneoplastic lymph nodes revealed CD138 reactivity only for nonneoplastic plasma cells, the neoplastic cells of 2 large B-cell lymphomas (immunoblastic type, plasmacytoid features), and the clonal plasma...
Patients' tumor tissues that expressed high levels of CD138 plasma cells (N=4) had a statistically significant improvement in OS compared to low levels of CD138 (N=9) (p=0.01). Although these findings are preliminary, the significance of CD138 expressing plasma cells within BM specimens ...
Cell Type B Cells, Plasma Species Mouse Sample Source Bone Marrow, Lymph Node, Other, Spleen Selection Method Positive Application Cell Isolation Brand EasySep, RoboSep Area of Interest Immunology Data Figures Figure 1. Typical EasySep™ Mouse CD138 Positive Cell Isolation Pr...
CD138 is not expressed by mature B cells but is present on pre-B cells and the finally differentiated plasma cells.Applications Reported: This MI15 antibody has been reported for use in flow cytometric analysis.Applications Tested: This MI15 antibody has been pre-diluted and tested by flow ...
[8] Zambello R, Barila G, Manni S, et al. NK cells and CD38: implication for (Immuno) therapy in plasma cell dyscrasias[J]. Cells, 2020, 9(3): 768. DOI: 10.3390/cells9030768. [9] Rawstron AC, Orfao A, ...
cellsbyflow~~ometry.Result:ThePRDM1expressioninSLEpatientsbloodwassignificantlyhigherthanthathealthy"group(P<0.05),andtheamountof CD138 plasmacellsarealsomorethanhealthygroup.Conclusion:PRDMIandtheamountofCD138 plasmacellsinSLEstudygroupissignificantlyhigher thancontrolgroup,indicatingthatthehighPRDM1expresionand...
-1 participates in cell proliferation, cellmigration, and cell matrix adhesion via interaction with collagen, fibronectin, and other solublemolecules (such as FGF-basic). It is expressed on normal and malignant plasma cells, pre-Bcells, mesenchymal cells, epithelial cells, and endothelial cells....
CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells.1,2 It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma.1 ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-ass...
However, its sensitivity is hampered due to paucity of plasma cells in whole bone marrow and often shows false-negative results when frequency of abnormal cells is below the cut-off values. Studies have shown that the abnormality detection rate in enriched plasma cells (EPC) is greater than ...
plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a ...