progenitor cellsCD138Clonogenic multiple myeloma (MM) cells reportedly lacked expression of plasma cell marker CD138. It was also shown that CD19clonotypic B cells can serve as MM progenitor cells in some patients. However, it is unclear whether CD138-negative clonogenic MM plasma cells are ...
批量或定制请求 Application Created with Sketch. 图:1/3 CD138 (Syndecan-1) Antibody (46-1388-42) in Flow Staining of in vitro generated human plasma cells. Enriched and stimulated B-cells were stained with CD19 Monoclonal Antibody, PE (Product # 12-0199-42), CD38 Monoclonal Antibody...
We found that PCs specific for viruses encountered more than 40 years prior to the study were exclusively contained within the CD19−CD38hiCD138+ subset. These cells have a distinct PC morphology, are predominantly non-cycling, and express many of the gene products implicated in LLPC function...
It is a heparan sulfate proteoglycan expressed on the surface of, and actively shed by, myeloma cells. Altered syndecan-1 expression has been detected in several different tumor types. CD138 was regarded as a useful marker for labeling normal and neoplastic plasma cells and plasmacytoid lymphomas....
The in vitro CD40-CD154 interaction promotes human B lymphocytes differentiation into plasma cells. Currently, CD138 is the hallmark marker enabling the detection of human plasma cells, both in vitro and in vivo; its presence can be monitored by flow cytometry using a specific antibody. We have...
Likewise, the fraction of CD19+ B cells (9.4%, normal 12.7 ± 5.4%) and CD138+ plasma cells (0.16%, normal 0.17 ± 0.14%) were normal in the PB. In contrast, flow cytometry of the CSF (Figure 1G, lower panels, CSF) revealed predominantly CD3+ CD56- T cells (95%...
cellsbyflow~~ometry.Result:ThePRDM1expressioninSLEpatientsbloodwassignificantlyhigherthanthathealthy"group(P<0.05),andtheamountof CD138 plasmacellsarealsomorethanhealthygroup.Conclusion:PRDMIandtheamountofCD138 plasmacellsinSLEstudygroupissignificantlyhigher thancontrolgroup,indicatingthatthehighPRDM1expresionand...
CD138 was regarded as a useful marker for labeling normal and neoplastic plasma cells and plasmacytoid lymphomas. CD138 has a calculated molecular weight of 32.5 kDa, the apparent molecular weight is higher due to extensive glycosylation. 实验方案 Product Specific Protocols WB protocol for CD138/...
Chimeric antigen receptor-modified T cells Multiple myeloma CD138 1. Introduction Multiple myeloma (MM) is a fatal plasma cell neoplasm affecting one to five per 100,000 individuals and constitutes the second most common hematological malignancy [1]. Despite the application of auto/allo-hematopoietic...
The CD138 molecule interacts with extracellular matrix proteins, cell surface molecules, and other soluble proteins. It is expressed on normal and malignant human plasma cells and on basolateral surfaces of endothelial cells but not on virgin/naive B cells, memory B cells, T cells, or monocytes....