Mononuclear cells were isolated using Ficoll-Paque, while CD138+ plasma cells were positively selected using magnetic beads with anti-CD138 mAbs. Next, miRNA-seq was performed in CD138+ plasma cells from MGUS (n=4), sMM (n=4) and MM (n=20) patients. Based on miRNA-seq, target ...
(B-cell, 49; T-cell, 8; Hodgkin lymphoma, 19), 1 Langerhans cell histiocytosis, and 14 nonneoplastic lymph nodes revealed CD138 reactivity only for nonneoplastic plasma cells, the neoplastic cells of 2 large B-cell lymphomas (immunoblastic type, plasmacytoid features), and the clonal plasma...
CD138 is not expressed by mature B cells but is present on pre-B cells and the finally differentiated plasma cells.Applications Reported: This MI15 antibody has been reported for use in flow cytometric analysis.Applications Tested: This MI15 antibody has been pre-diluted and tested by flow ...
[8] Zambello R, Barila G, Manni S, et al. NK cells and CD38: implication for (Immuno) therapy in plasma cell dyscrasias[J]. Cells, 2020, 9(3): 768. DOI: 10.3390/cells9030768. [9] Rawstron AC, Orfao A, ...
CD138 is not expressed by mature B cells but is present on pre-B cells and the finally differentiated plasma cells.Applications Reported: This MI15 antibody has been reported for use in flow cytometric analysis.Applications Tested: This MI15 antibody has been pre-diluted and tested b...
cellsbyflow~~ometry.Result:ThePRDM1expressioninSLEpatientsbloodwassignificantlyhigherthanthathealthy"group(P<0.05),andtheamountof CD138 plasmacellsarealsomorethanhealthygroup.Conclusion:PRDMIandtheamountofCD138 plasmacellsinSLEstudygroupissignificantlyhigher thancontrolgroup,indicatingthatthehighPRDM1expresionand...
CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells.1,2 It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma.1 ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-ass...
-1 participates in cell proliferation, cellmigration, and cell matrix adhesion via interaction with collagen, fibronectin, and other solublemolecules (such as FGF-basic). It is expressed on normal and malignant plasma cells, pre-Bcells, mesenchymal cells, epithelial cells, and endothelial cells....
The cluster of differentiation antigen (CD Antigens) 138 or syndecan-1 (Syndecans) refers to a cell marker present on the surface of normal and malignant plasma cells as well as the basolateral surface of endothelial cells. It is not however, detected on naïve nor memory B cells, T cell...
cellsbyflow~~ometry.Result:ThePRDM1expressioninSLEpatientsbloodwassignificantlyhigherthanthathealthy"group(P<0.05),andtheamountof CD138 plasmacellsarealsomorethanhealthygroup.Conclusion:PRDMIandtheamountofCD138 plasmacellsinSLEstudygroupissignificantlyhigher thancontrolgroup,indicatingthatthehighPRDM1expresionand...