Several types of dendritic cells, such as bone marrow-derived dendritic cells (GM-CSF cultured or FLT3-ligand induced) or monocyte-derived ones, are powerful adjuvants, although GM-CSF-cultured cells show the highest activity. Among these, the CD11c + MHCII lo sub-set, distinguishable by a ...
GM-CSF-BMDCs were sorted based on expression of CD11c and MHC class II into three sub-populations similar to the sorting strategy adopted earlier [33] (Fig.3a): undifferentiated cells without CD11c and MHCII expression (P7), CD11c+MCHIIlocells (P6) and CD11c+MHCIIhicells (P5). P5 and ...
CD11c(+) MHCIIlo GM-CSF-bone marrow-derived dendritic cells act as antigen donor cells and as antigen presenting cells in neoepitope-elicited tumor ... H Ebrahimi-Nik,WL Corwin,Shcheglova, TatianaDas Mohapatra, AlokMandoiu, Ion I.Srivastava, Pramod K. - 《Cancer Immunology Immunotherapy》 被...
CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression...
Pathogen-mimicking Nanoparticles Based on Rigid Nanomaterials as an Efficient Subunit Vaccine Delivery System for Intranasal Iimmunization mouseFC Int J Biol Macromol Mucoadhesive chitosan-catechol as an efficient vaccine delivery system for intranasal immunization ...
CD11b+DCs have higher expression of MHC-II presentation machinery than CD8+DCs and are more effective atantigen presentationto CD4+T cellsin the steady state and inflammation (Dudziak et al., 2007). Although CD11b+DCs are inferior to CD8+/CD103+DCs in priming naïve CD8+T cells, they ...
Several types of dendritic cells, such as bone marrow-derived dendritic cells (GM-CSF cultured or FLT3-ligand induced) or monocyte-derived ones, are powerful adjuvants, although GM-CSF-cultured cells show the highest activity. Among these, the CD11c+ MHCIIlo sub-set, distinguishable by a dist...
Tetramers are multimers of peptide–MHC II molecules that can bind to the antigen-specific T-cell receptor. TGF-β TGF-β is a pleiotropic growth factor produced by epithelial cells and inflammatory cells, including eosinophils, mast cells, and T cells. TGF-β1 can have profibrotic effects, ...
mDC myeloid Dendritic Cell 髓样树突状细胞 MHC Major histocompatibility complex 主要组织相容性复合体 MLR Mixed leukocyte reaction 混合淋巴细胞反应 moDC Monocyte-derived Dendritic Cells 单核细胞来源树突状细胞 MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2h- ...
Koanhoi Kim3 & Seong Kug Eo1,2 Although the roles of dendritic cells (DCs) in adaptive defense have been defined well, the contribution of DCs to T cell-independent innate defense and subsequent neuroimmunopathology in immune-privileged CNS upon infection with neurotropic viruses has not...