后来有人把肿瘤抗原小分子肽与白细胞介素2一同给药,这样可以增加免疫反应,但临床疗效还是有限。也有人把小分子肽从10到12个氨基酸(MHCII),加長到20个氨基酸,并配以树突状细胞的佐剂以提高免疫反应,临床效果也并不太明显。目前,有人干脆就把肿瘤相关抗原加佐剂输入病人,这样,也许被树突状细胞处理过的多肽表达到细...
The expression of MHC class II (MHC-II) on the surface of antigen-presenting cells, such as dendritic cells (DCs), is tightly regulated during cellular activation. Many cells, including DCs, are activated following stimulation of innate Toll-like receptors (TLRs) by products of microorganisms. ...
淋巴树突状细胞和髓系树突状细胞分别由淋巴树突状细胞和髓系前体细胞进化而来,因此具有造血起源。相比之下,滤泡树突状细胞(FDC) 可能具有间充质起源而非造血起源,并且不表达MHC II 类,但由于它们位于淋巴滤泡中并具有较长的“树突状”突起而得名。 血液中 血液中的树突状细胞通常用流式细胞术来识别和计数。在人类...
et al. Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation. Blood 116, 2277–2285 (2010). Article CAS PubMed Google Scholar Tsuji, T. et al. Antibody-targeted NY-ESO-1 to mannose receptor or DEC-205 in vitro elicits dual human...
cells that can express MHC class II molecules and that have been suggested to represent 'atypical' antigen-presenting cells. We consider whether any of these cell populations can prime naive CD4+T cells and, if not, question the effects that they do have on the development of immune responses...
Dendritic cells (DCs) and B cells present antigen-derived peptides bound to MHC class II (MHC II) molecules for recognition by CD4-positive T lymphocytes. DCs control the intracellular traffic of peptide-MHC II complexes by regulating the ubiquitination of MHC II. In resting or "immature" DCs...
Although intracellular endosomal processing in dendritic cells and B cells has been characterized for a few antigens, the overall range of processing pathways responsible for generating the MHC II peptidome are currently unclear. To determine the contribution of non-endosomal processing pathways, we ...
MHC class Ⅱmolecules are expressed on B cells, dendritic cells and macrophages, efficient APCs for the activation of CD4+ helper T cells. 青云英语翻译 请在下面的文本框内输入文字,然后点击开始翻译按钮进行翻译,如果您看不到结果,请重新翻译!
研究最多的有IL-10、维他命D3、糖皮质激素(如地米)、雷帕霉素(Rapamycin)和TGF-b等,而促进DC细胞成熟的因素也很多,比如肿瘤坏死因子、LPS,甚至replate等实验操作步骤均可以不同程度的促进DC细胞成熟。不过这三种状态的DC细胞是可以通过检测表面marker,如MHCII分子、CD80、CD83、CD86等的表达水平而区分开。
Objectives: Although MHC class II molecules can be expressed on dendritic cells (DC), macrophages and B-cells in lymph nodes and have the potential to activate CD4 T cells, it is believed that the dendritic cells are the major antigen presenting cells for T lymphocytes. They are located at ...