CD133作为HSOC表面抗原，在正常以及异常的造血组织和非造血组织中，均有表达，随着细胞的分化，CD133的表达会减弱，甚至是消失。Heo SK等研究表明，AML患者的骨髓中CD133细胞高表达，在分离自AML和慢性髓细系白血病（chronic myeloid leukemia,CML）患者的骨髓培养中显著检测到白血病干细胞（leukemia stem cells,LSC）...
巨噬細胞 myeloid cellsrecurrent tumorbrain tumorprimary tumormacrophageMalignant glioma is one of the toughest tumors to be treated at present due to the complexity of the tumor microenvironment and the intrinsic resistant to therapy. Previous studies have shown that CD11b+ myeloid cells play ...
Heo SK等研究表明,AML患者的骨髓中CD133细胞高表达,在分离自AML和慢性髓细系白血病(chronic myeloid leukemia,CML)患者的骨髓培养中显著检测到白血病干细胞(leukemia stem cells,LSC),研究结果说明AML中的CD133细胞潜在地充当了LSC。 CD11b在白血病的原始细胞、自然杀伤细胞、成熟的单核细胞、粒细胞中表达,分布在骨髓...
cells to the lung in an attempt to wall off bacilli by forming a granuloma. Gr1(int)CD11b(+) cells are called myeloid-derived suppressor cells (MDSC) and play a major role in regulation of inflammation in many pathological conditions. Although MDSC have been described primarily in cancer ...
Heo SK等研究表明,AML患者的骨髓中CD133细胞高表达,在分离自AML和慢性髓细系白血病(chronic myeloid leukemia,CML)患者的骨髓培养中显著检测到白血病干细胞(leukemia stem cells,LSC),研究结果说明AML中的CD133细胞潜在地充当了LSC。 CD11b在白血病的原始细胞、自然杀伤细胞、成熟的单核细胞、粒细胞中表达,分布在骨髓...
Description: The CBRM1/5 monoclonal antibody reacts with an activation-specific epitope of human Mac-1. CBRM1/5 binds a subset of Mac-1 molecules on neutrophils and monocytes after stimulation with chemoattractants or phorbol esters but does not recognize Mac-1 on resting myeloid cells. Through...
骨髓来源的抑制性细胞(Myeloid-derived suppressor cells，MDSCs)是骨髓来源的一群异质性细胞，是树突状细胞(dendritic cells，DCs)、巨噬细胞和(或)粒细胞的前体，具有显著抑制免疫细胞应答的能力。小鼠MDSCs的表型为CD11b+Gr-1+，分两个亚型:粒细胞样的MDSCs(CD11b+Ly6C-Ly6G+)和单核细胞样的MDSCs...
参考文献:Hänninen, Arno et al. “Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes.” European journal of immunology vol. 41,3 (2011): 634-44. doi:10.1002/eji.201040760 Fleming, T J et al. “Sel...
Granulocytes and Subsets, Monocytes, Myeloid Cells Species Mouse Sample Source Bone Marrow, Other, Whole Blood Selection Method Negative Application Cell Isolation Brand EasySep Area of Interest Immunology View More Data Figures Figure 1.Typical EasySep™ Mouse MDSC (CD11b+Gr1+) Cell Isolation Profile...
CD11b is expressed by, and commonly used as a marker for, myeloid lineage cells, including neutrophils, monocytes, macrophages, and microglia (2). CD11b is phosphorylated at Ser1126 (cytoplasmic tail) in neutrophils. Research has shown that this phosphorylation event plays a role for leukocytes ...