Here, we describe a unique type of APC, Gr1−/lowCD11b−/low cells with a granularity and size characteristic of myeloid cells and with the ability to present Ag for crosspresentation. These cells constitutively express MHCII and the costimulatory molecules, CD80, CD86, and CD40. They do...
Gr1(+)CD11b(+) cells expressed high levels of arginase-1, and IL-17, additional markers of myeloid derived suppressor cells. We then sorted the Gr1(hi) and Gr1(int) populations from M. tuberculosis infected NOS-/- mice and placed the sorted both Gr1(int) populations at different ratios ...
答:Gr-1单抗通常认为是粒细胞标记,但实际上,它既可结合Ly-6G也可结合Ly-6C。大多数 Gr1+ CD11b- 细胞是 Ly6C+ LyG-,Ly6C可表达在浆细胞、部分粒细胞和T 细胞(包括记忆 T 细胞)表达。所以Gr1+ CD11b-细胞可能CD8是阳性的,如果补做CD8是阳性的...
Gr-1(+) cells could be found on the edges of necrotic lung lesions in NOS2-/-, RAG-/-, and C3HeB/FeJ, but were absent in wild-type mice. Both populations of Gr1(+)CD11b(+) cells expressed high levels of arginase-1, and IL-17, additional markers of myeloid derived suppressor ...
Although the Gr1int cells are readily detectable in the lung tissue of LPS-treated mice, they are not detected in the lung-draining lymph nodes or in the airway lumen which causes selective enrichment of these cells over dendritic cells (DCs) in the tissue. The Gr1int cells were found to ...
Furthermore, adoptive transfer of CD11b+ Gr1dim tolDC-LCs significantly suppressed the progression of ILD in SKG mice.We identified a unique suppressive myeloid cells termed CD11b+ Gr1dim tolDC-LCs, which were differentiated from M-MDSCs, in ILD of SKG mice. This article is protected by ...
The cells were also examined for the expression of F4/80, which is not expressed by neutrophils.10,11 Although the neu- trophils were F4/80 − , the Gr1int cells were F4/80 + . Collectively, the features of the Gr1int cells resembled those of myeloid- derived suppressor cells (MDSCs...
Granulocytes and Subsets, Monocytes, Myeloid Cells Species Mouse Sample Source Bone Marrow, Other, Whole Blood Selection Method Negative Application Cell Isolation Brand EasySep Area of Interest Immunology View More Data Figures Figure 1.Typical EasySep™ Mouse MDSC (CD11b+Gr1+) Isolation Kit Profile...
by reducing myeloid cell recruitment Qian-Qian Zhang1,*, Xi-Wen Hu1,*, Yi-Long Liu1, Zhi-Jin Ye1, Yi-He Gui1, Da-Lei Zhou1, Cui-Ling Qi1, Xiao-Dong He1, Honglin Wang2 & Li-Jing Wang1 Mac-1 (CD11b) is expressed on bone marrow-derived immune cells. ...
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells Vascular endothelial growth factor (VEGF) is an essential regulator of normal and abnormal blood vessel growth. A monoclonal antibody (mAb) that targets VE... F Shojaei,X Wu,AK Malik,... - 《Nature ...