Granulocytes and Subsets, Monocytes, Myeloid Cells Species Mouse Sample Source Bone Marrow, Other, Whole Blood Selection Method Negative Application Cell Isolation Brand EasySep Area of Interest Immunology View More Data Figures Figure 1.Typical EasySep™ Mouse MDSC (CD11b+Gr1+) Cell Isolation Profile...
CPI-613 treated mice showed significantly improved overall survival (median survival 75 days versus 48 days in control), decreased tumor progression and burden.CPI-613 decreased the number of CD11b+Gr1+ myeloid cells in ascites, and more importantly, reduced the intracellular immunosuppressive markers...
Gr1(+)CD11b(+) cells expressed high levels of arginase-1, and IL-17, additional markers of myeloid derived suppressor cells. We then sorted the Gr1(hi) and Gr1(int) populations from M. tuberculosis infected NOS-/- mice and placed the sorted both Gr1(int) populations at different ratios ...
答:Gr-1单抗通常认为是粒细胞标记,但实际上,它既可结合Ly-6G也可结合Ly-6C。大多数 Gr1+ CD11b- 细胞是 Ly6C+ LyG-,Ly6C可表达在浆细胞、部分粒细胞和T 细胞(包括记忆 T 细胞)表达。所以Gr1+ CD11b-细胞可能CD8是阳性的,如果补做CD8是阳性的...
采用小鼠4T1乳腺癌模型观察MSC通过CD11b+Gr1+细胞对肿瘤生长的影响.结果 MSC能够促进骨髓中CD11b+Gr1+细胞的存活和生成,同时可诱导正常小鼠骨髓中CD11b+Gr1+细胞对T细胞的抑制作用.动物实验结果显示,MSC处理后的骨髓CD11b+Gr1+细胞可以促进肿瘤的生长,加速小鼠的死亡.结论 MSC可以通过促进骨髓来源的CD11b+Gr1+细胞...
Furthermore, adoptive transfer of CD11b+ Gr1dim tolDC-LCs significantly suppressed the progression of ILD in SKG mice.We identified a unique suppressive myeloid cells termed CD11b+ Gr1dim tolDC-LCs, which were differentiated from M-MDSCs, in ILD of SKG mice. This article is protected by ...
Gr-1(+) cells could be found on the edges of necrotic lung lesions in NOS2-/-, RAG-/-, and C3HeB/FeJ, but were absent in wild-type mice. Both populations of Gr1(+)CD11b(+) cells expressed high levels of arginase-1, and IL-17, additional markers of myeloid derived suppressor ...
14. Our data also showed that Gr-1+CD11b+ myeloid cells were mostly the bone-marrow cells and spleen cells in tumor bearing mice (Fig. 1A), suggesting that Gr-1+CD11b+ myeloid cells may play a more important role than other CD11b+cells in tumor neo-vasculature. This speculation ...
The cells were also examined for the expression of F4/80, which is not expressed by neutrophils.10,11 Although the neu- trophils were F4/80 − , the Gr1int cells were F4/80 + . Collectively, the features of the Gr1int cells resembled those of myeloid- derived suppressor cells (MDSCs...
Tumor-associated factors are related to increased accumulation of CD11b+Gr1+myeloid-derived suppressor cells (MDSCs). However, the exact mechanism of how genetic factors control the expansion of MDSCs in tumor-bearing hosts remains elusive. Herein, we found that tumor-associated MDSCs and their ...