cells (ECs) enable the recruitment of circulating monocytes to sites of endothelial injury and inflammation, followed by migration towards distinct cytokine and chemokine gradients [3]. In the inflammatory milieu attracted monocytes mature into foamy macrophages upon ...
CD11[b.sup.+]Ly6[C.sup.++]Ly6[G.sup.-] cells with suppressive activity towards T cells accumulate in lungs of influenza a virus-infected miceFluorochrome-coupled antibodies recognizing mouse CD3 (clone 145-2C11), CD4 (RM4-5), CD11b (...
CD11[b.sup.+]Ly6[C.sup.++]Ly6[G.sup.-] cells with suppressive activity towards T cells accumulate in lungs of influenza a virus-infected miceFluorochrome-coupled antibodies recognizing mouse CD3 (clone 145-2C11), CD4 (RM4-5)... P Milanez-Almeida,T Ulas,M Pasztoi,... 被引量: ...
Human polymorphonuclear leukocytes (PMN) released large quantities of hydrogen peroxide in response to tumor necrosis factor, but only when the cells were ... Nathan,C. - 《Journal of Cell Biology》 被引量: 3656发表: 1989年 Identification of surface proteins mediating adherence of CD11/CD18-def...
树突状细胞(Dendriticcells,DCs)是目前所知 体内功能最强大的专职抗原提呈细胞,是连接天然 免疫应答和适应性免疫应答的桥梁,也是体内唯一 能够激活初始T细胞的APC(Antigenpresenting cell)。CD11c被称为补体受体4(Complement receptor,CR4),是黏附分子CD11/CD18家族中的一 员,属于Ⅰ型跨膜糖蛋白,高表达于髓系DCs表 ...
Of four anti-rabbit CD18 Mabs tested, only one, L13/64, has been shown to be capable of inhibiting the adhesion of fMLP-stimulated neutrophils to gelatin coated plastic and the homotypic aggregation of PMA-stimulated T cells, both of which assays have been shown to be CD18-dependant. RC...
Variable expression of activation-linked surface antigens on human mast cells in health and disease Summary: Mast cells (MC) are multipotent effector cells of the immune system. They contain an array of biologically active mediator substances in their gra... P.,Valent,G.-H.,... - 《Immunolo...
Adhesion of activated leukocytes to cells is of critical functional importance. The adhesion is known to be mediated mainly by the CD11/CD18 integrins, also known as leukocytic cell adhesion molecules, or Leu-CAM. We have now studied the phosphorylation of Leu-CAM by protein kinase C and the...
CD14, which exists as a GPI-anchored and a soluble protein, lacks cytoplasmic-signaling domains, suggesting that an ancillary molecule is required to activate cells. The CD11/CD18 integrins are transmembrane proteins. Like CD14, they are capable of mediating LPS-induced cellular activation when ...
We have examined the contributions of endothelial-leukocyte adhesion molecule-1 (ELAM-1) and the complex of leukocyte surface adhesion molecules designated CD11/CD18 to the adhesion of human polymorphonuclear leukocytes (PMN) to cultured human endothelial cells (HEC), activated by rIL-1 beta for ...