其次,为了理解ABC在疫苗免疫模型中的功能,作者将B细胞特异Zeb2敲除的抗疟原虫抗原特异性B细胞(CD23cre/Zeb2fl/flIghg2A10B cell)转移至MD4小鼠,并通过辐照疟原虫疫苗免疫它们。正如预期,研究发现CD23cre/Zeb2fl/flIghg2A10B cell 不能形成ABC。然而,无论Zeb2缺失与否,小鼠的生发中心(germinal center,GC)B细胞和浆...
CD11c(hi)MHC II(med) cells promote endothelial cell quiescence in vitro and, in vivo, mediate quiescence at least in part by mediating reduced lymph node vascular endothelial growth factor. Disrupted vascular quiescence and stabilization in expanded nodes is associated with attenuated T cell-dependent...
CD11c is a cell-surface antigen that is expressed on granulocytes, monocytes, natural killer cells and small populations of normal T and B lymphocytes. From:Best Practice & Research Clinical Haematology,2003 Chapters and Articles You might find these chapters and articles relevant to this topic. ...
Although the roles of dendritic cells (DCs) in adaptive defense have been defined well, the contribution of DCs to T cell-independent innate defense and subsequent neuroimmunopathology in immune-privileged CNS upon infection with neurotropic viruses has not been completely defined. Notably, DC roles...
最后在临床样本中观察到RAB27A的表达异常。这项工作揭示了胃肠道炎症相关外泌体介导的调节机制,并为使用含有miRNA的外泌体作为炎症性肠疾病的新疗法铺平了道路。 参考文献:CD11c+ myeloid cell exosomes reduce intestinal inflammation during ...
To determine the effect of the MSCs on the CD11c+ cell phenotype, we performed a trans-well experiment. Briefly, the CD11c+ cells (0.5 × 106 cells) were directly seeded onto MSCs (3.3 × 105) in the lower trans-well system, or separated from the MSCs in the upper t...
Koanhoi Kim3 & Seong Kug Eo1,2 Although the roles of dendritic cells (DCs) in adaptive defense have been defined well, the contribution of DCs to T cell-independent innate defense and subsequent neuroimmunopathology in immune-privileged CNS upon infection with neurotropic viruses has not...
Objectives: Here, we have identified a novel immune cell population expressing mPDCA-1 Ag in lymphoid tissues, which are mPDCA1 + CD11c TcR B220 . Studies were conducted to investigate the in vivo function of this cell population in t... Jae㎏wang Yoo,E Fish - 《Faseb Journal》 被引量...
Although splenocytes cocultured with MSCs showed reduced T cell proliferation and expansion of CD4+FoxP3+ regulatory T cells (Tregs), depletion of CD11c+ cells was associated with partial loss of MSCs effect on T cells. In in-vivo experiment, MSCs' renoprotective effect was also associated ...
Collectively, these data suggest that Ag challenge stimulates CD11c(+) cells to produce cytokines and/or chemokines required for VCAM-1 upregulation on the lung endothelium, which in turn is crucial for the Ag-induced mast cell progenitor recruitment and the increase in mast cell numbers. 展开 ...