2023年3月22日,天津中医药大学现代中医药国家重点实验室Guanwei Fan团队在《Advanced Science》上发表题为“M2 Macrophage-DerivedsEVRegulate Pro-Inflammatory CCR2+ Macrophage Subpopulations to Favor Post-AMI Cardiac Repair”的文章,他们表明M2巨噬细胞来源的细胞外囊泡(sEV)通过mir -181b-5p依赖机制调节CCR2+...
但心梗后,心脏常驻巨噬细胞大量丢失且恢复缓慢,给心梗修复带来了巨大的挑战。 基于此,王乐禹教授、邱小忠教授团队近期在【Cell Reports Medicine】杂志上发表"A functional cardiac patch promotes cardiac repair by modulating the CCR2− cardiac-resident macrophage niche and their cell crosstalk"的相关研究成果。
但心梗后,心脏常驻巨噬细胞大量丢失且恢复缓慢,给心梗修复带来了巨大的挑战。 基于此,王乐禹教授、邱小忠教授团队近期在【Cell Reports Medicine】杂志上发表"A functional cardiac patch promotes cardiac repair by modulating the CCR2− cardiac-resident macrophage niche and their cell crosstalk"的相关研究成果。
M2 macrophage accumulation contributes to pulmonary fibrosis, vascular dilatation, and hypoxemia in rat hepatopulmonary syndrome. J Cell Physiol. 2021;236:7682–97. Article CAS PubMed Google Scholar Xi S, Zheng X, Li X, Jiang Y, Wu Y, Gong J, et al. Activated hepatic stellate cells induce...
High‐fat diet‐induced dysbiosis mediates MCP‐1/CCR2 axis‐dependent M2 macrophage polarization and promotes intestinal adenoma‐adenocarcinoma sequencegut microbiotahigh‐fat dietintestinal carcinogenesisMCP‐1/CCR2 axistumour‐associated macrophages
5月17日,Theranostics在线发表了中山大学药学院冯敏教授团队的最新成果“Proinflammatory macrophage-derived microvesicles exhibit tumor tropism dependent on CCL2/CCR2 signaling axis and promote drug delivery via SNARE-mediated membrane fusion”。作者采用差速超速离心分离促炎症巨噬细胞来源的细胞外囊泡亚群,包括凋...
they can be divided into M1 macrophages (the classical activation state), which participate in the proinflammatory response, and M2 macrophages (the alter- native activation state), which have roles in inhibiting the inflammatory response.21–24 Each macrophage activation state has a different gene ...
Kashyap 等[23] 发现在 RVH 小 鼠模 型中 CCR2 的药理阻断可显著减少 F4 / 80+ CD206+ M2 型巨噬细胞在肾脏中的浸润,同时降低 肾脏中 CCL5 和 TNF⁃α 的表达水平. 综上, 阻断 CCR2 可能为临床 RVH 治疗提供一种新方法. 梗阻性肾病( ON) ON 是 CKD 和 ESRD 的常 见病因之一,其主要病理学...
Methods: Newly developed CCR2 and CD163 tracers were both radiolabeled with 68Ga and employed to determine the dynamic changes in M1 and M2 macrophage subsets through serial PET imaging, histopathological and immunostaining analyses, flow cytometry, and autoradiography studies using a post-MI mouse ...
19,20 Diet-induced obesity polarizes ATMs from an M2 to M1 proinflammatory state.15,21 Thus, interventions that disrupt macrophage recruitment into the AT, block M1-polarization of macrophages, and/or attenuate AT inflammation may alleviate the metabolic syndrome associated with obesity.22,23 In ...