2023年3月22日,天津中医药大学现代中医药国家重点实验室Guanwei Fan团队在《Advanced Science》上发表题为“M2 Macrophage-Derived sEV Regulate Pro-Inflammatory CCR2+ Macrophage Subpopulations to Favor Post-AMI Cardiac Repair”的文章,他们表明M2巨噬细胞来源的细胞外囊泡(sEV)通过mir -181b-5p依赖机制调节CCR2...
M2巨噬细胞衍生的sEV调节促炎CCR2+巨噬细胞亚群有利于AMI后心脏修复 2023年3月22日,天津中医药大学现代中医药国家重点实验室Guanwei Fan团队在《Advanced Science》上发表题为“M2 Macrophage-Derived sEV Regulate Pro-Inflammatory CCR2+ Macrophage Subpopulations to Favor Post-AMI Cardiac Repair”的文章,他们表明...
胞外囊泡主要由凋亡小体(Apoptosis Body,APB)、微囊泡(Microvesicles, MIV)和外泌体(Exosomes, Exo)组成。基于外泌体的化疗药物递送系统已被广泛研究,然而其他亚型的细胞外囊泡,特别是微囊泡的治疗潜力似乎被忽视了。 5月17日,Theranostics在线发表了中山大学药学院冯敏教授团队的最新成果“Proinflammatory macrophage...
M2 macrophage accumulation contributes to pulmonary fibrosis, vascular dilatation, and hypoxemia in rat hepatopulmonary syndrome. J Cell Physiol. 2021;236:7682–97. Article CAS PubMed Google Scholar Xi S, Zheng X, Li X, Jiang Y, Wu Y, Gong J, et al. Activated hepatic stellate cells induce...
High‐fat diet‐induced dysbiosis mediates MCP‐1/CCR2 axis‐dependent M2 macrophage polarization and promotes intestinal adenoma‐adenocarcinoma sequencegut microbiotahigh‐fat dietintestinal carcinogenesisMCP‐1/CCR2 axistumour‐associated macrophages
近日,来自法国和比利时的学者在呼吸领域权威杂志EUROPEAN RESPIRATORY JOURNAL中发表了题为CCR2/CCR5-Mediated Macrophage-Smooth Muscle Cell Crosstalk in Pulmonary Hypertension的文章,该研究首次证实了在PAH早期,巨噬细胞和PASMCs中CCR2和CC...
they can be divided into M1 macrophages (the classical activation state), which participate in the proinflammatory response, and M2 macrophages (the alter- native activation state), which have roles in inhibiting the inflammatory response.21–24 Each macrophage activation state has a different gene ...
macrophage,TAM)的趋化作用形成肿瘤转移前微环境,为肿瘤细胞 的定植提供适宜的环境[4]。外源性CCL2已被证明可以通过有丝 分裂原活化蛋白激酶(MAPK)信号通路促进卵巢癌细胞的增殖[5]。 CCR2是一种G蛋白耦联受体,包括CCR2A和CCR2B两个亚型,表达 于树突状细胞、单核细胞、T淋巴细胞等多种免疫细胞表面[6]。 CCL...
Mass cytometry confirmed that M2 macrophages played an important role during fibrosis, while macrophage-depleted mice exhibited significantly reduced transforming growth factor-β (Tgf-β) levels in heart tissue after MIR. In co-culture of macrophages with fibroblasts, treatment with recombinant mouse ...
Kashyap 等[23] 发现在 RVH 小 鼠模 型中 CCR2 的药理阻断可显著减少 F4 / 80+ CD206+ M2 型巨噬细胞在肾脏中的浸润,同时降低 肾脏中 CCL5 和 TNF⁃α 的表达水平. 综上, 阻断 CCR2 可能为临床 RVH 治疗提供一种新方法. 梗阻性肾病( ON) ON 是 CKD 和 ESRD 的常 见病因之一,其主要病理学...