【2】M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry Y Sun, et al. iScience 2021,24(11),103339 (3) 肿瘤细胞 与正常细胞相比,肿瘤细胞对Ca2+浓度更敏感。细胞内Ca2+浓度失衡时,线粒体作为传感器和调节器,从细胞质中吸收Ca2+,调节Ca2+稳态。当Ca2+超载时,肿瘤细胞中线粒体Ca2+...
Finally, alterations in TRPC1 or Orai1 expression determine macrophage polarization suggesting a distinct role of Ca2+channels in modulating macrophage transformation.doi:10.1016/j.isci.2021.103339V.Nascimento Da ConceicaoY.SunK.RamachandranA.Chauhan...
[3]. Kim S, et al. Upregulation of heme oxygenase-1 by ginsenoside Ro attenuates lipopolysaccharide-induced inflammation in macrophage cells. J Ginseng Res. 2015 Oct;39(4):365-70. [4]. Jiang Z, et al. The traditional Chinese medicine Achyranthes bidentata and our de novo conception of i...
The reason why local Ca2+ increases lead to the depolymerization of actin filaments at the vicinity of membranes of the macrophage phagosome or bacteria-containing vacuole, while promoting actin polymerization at Shigella invasion site is unclear and may be related to the local environment or the ...
We first tested the role of Ca2+signaling in macrophage efferocytosis. BMDMs were loaded with either BAPTA-AM or EGTA-AM Ca2+chelators prior to incubation with labeled apoptotic cells. Although BAPTA and EGTA have similar affinities for Ca2+, they exhibit very different kinetics of Ca2+-binding...
Ca2+ mobilization in the rat alveolar macrophage cell line NR8383 was examined with the Ca2+-sensitive fluorescent probe Fura-2. ATP and norepinephrine elicited a 108 and 46% increase, respectively, in cytosolic free Ca2+ concentration ([Ca2+]i). Acetylcholine, nicotine, isoproterenol, substance ...
Micro/Macro, Microglia and Macrophage; NFO, Newly-formed oligodendrocyte; MOL, Myelinating oligodendrocyte. n = 2; each biological replicate consists of pooled cells from a litter of 3–12 mice19. (b) Single cell RNA-seq expression of zebrafish dlg4 (a/b), gephyrin (a/b), and ...
[39] ELLOUMI H Z,MAHARSHAK N,RAO K N,et al. A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis[J]. PLoS One,2012,7(3):e34172. [40] KYTTARIS V C,...
The specific role of SOCE in macrophage and DC function, as well as its contribution to innate immunity, however, is not well defined. We found that nonselective inhibition of Ca(2+) signaling strongly impairs many effector functions of bone marrow-derived macrophages and bone marrow-derived ...
Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its ... Schober,A. - 《Circulation》 被引量: 411发表: 2004年 Adaptive immunity in atherogenesis: new insights and therapeutic approaches Many remarkabl...