【2】M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry Y Sun, et al. iScience 2021,24(11),103339 (3) 肿瘤细胞 与正常细胞相比,肿瘤细胞对Ca2+浓度更敏感。细胞内Ca2+浓度失衡时,线粒体作为传感器和调节器,从细胞质中吸收Ca2+,调节Ca2+稳态。当Ca2+超载时,肿瘤细胞中线粒体Ca2+...
[3]. Kim S, et al. Upregulation of heme oxygenase-1 by ginsenoside Ro attenuates lipopolysaccharide-induced inflammation in macrophage cells. J Ginseng Res. 2015 Oct;39(4):365-70. [4]. Jiang Z, et al. The traditional Chinese medicine Achyranthes bidentata and our de novo conception of i...
The reason why local Ca2+ increases lead to the depolymerization of actin filaments at the vicinity of membranes of the macrophage phagosome or bacteria-containing vacuole, while promoting actin polymerization at Shigella invasion site is unclear and may be related to the local environment or the ...
Macrophage arachidonate-mobilizing phospholipase A2: role of Ca2' for membrane binding but not for catalytic activity - Wijkander, Sundler - 1992 () Citation Context ...ting with ionophore. By either pathway the synthesis of PAF requires Ca2+ influx. In recent years several mammalian PLA2s ...
We first tested the role of Ca2+signaling in macrophage efferocytosis. BMDMs were loaded with either BAPTA-AM or EGTA-AM Ca2+chelators prior to incubation with labeled apoptotic cells. Although BAPTA and EGTA have similar affinities for Ca2+, they exhibit very different kinetics of Ca2+-binding...
[39] ELLOUMI H Z,MAHARSHAK N,RAO K N,et al. A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis[J]. PLoS One,2012,7(3):e34172. [40] KYTTARIS V C,...
Ca2+ mobilization in the rat alveolar macrophage cell line NR8383 was examined with the Ca2+-sensitive fluorescent probe Fura-2. ATP and norepinephrine elicited a 108 and 46% increase, respectively, in cytosolic free Ca2+ concentration ([Ca2+]i). Acetylcholine, nicotine, isoproterenol, substance ...
Micro/Macro, Microglia and Macrophage; NFO, Newly-formed oligodendrocyte; MOL, Myelinating oligodendrocyte. n = 2; each biological replicate consists of pooled cells from a litter of 3–12 mice19. (b) Single cell RNA-seq expression of zebrafish dlg4 (a/b), gephyrin (a/b), and ...
The specific role of SOCE in macrophage and DC function, as well as its contribution to innate immunity, however, is not well defined. We found that nonselective inhibition of Ca(2+) signaling strongly impairs many effector functions of bone marrow-derived macrophages and bone marrow-derived ...
Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its ... Schober,A. - 《Circulation》 被引量: 411发表: 2004年 Adaptive immunity in atherogenesis: new insights and therapeutic approaches Many remarkabl...