These events led to the modulation of M2 polarization of macrophages, which eventually contributed to the alleviation of pulmonary fibrosis. Our results revealed a novel mechanism that may account for therapeutic effect of microcystin-LR on IPF....
Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages. Sci Rep 2016; 6: 29914.Huber, R. et al. Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages. Sci. Rep. 6, 29914 (2016)....
Beiging of white adipose tissue (WAT) is associated with an increase of anti-inflammatory M2-like macrophages in WAT. However, mechanisms through which M2-like macrophages affect beiging are incompletely understood. Here, we show that the macrophage cyto
M2-likemacrophagesinadipose tissuescreateamicroenvironmentthatinhibitsgrowthanddifferentiationofadipocyte progenitorsand,thereby,controladiposityandsystemicinsulinsensitivity. DOI:10.1038/s41467-017-00231-1OPEN 1 FirstDepartmentofInternalMedicine,UniversityofToyama,2630Sugitani,Toyama-shi,Toyama930-0194,Japan. 2 Depar...
Pro-inflammatory (M1-like) macrophages have been shown to release several mediators of cell behavior such as IL-6, IL-1b, and TNF-a, that are osteoclastogenic, while pro-healing (M2-like) macrophages are associated with the release of osteoblastogenic signaling molecules. The emergence of "...
Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages Ludovica Barone, Martina Cucchiara, Maria Teresa Palano, Barbara Bassani, Matteo Gallazzi, Federica Rossi,...
ARTICLE DOI: 10.1038/s41467-017-00231-1 OPEN CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors Allah Nawaz1, Aminuddin Aminuddin 1,2, Tomonobu Kado1, Akiko Takikawa1, Seiji Yamamoto3, Koichi Tsuneyama4,5, Yoshiko Igarashi6, ...
Adipose tissue resident macrophages have important roles in the maintenance of tissue homeostasis and regulate insulin sensitivity for example by secreting pro-inflammatory or anti-inflammatory cytokines. Here, we show that M2-like macrophages in adipose tissue regulate systemic glucose homeostasis by inhibi...
Macrophages (M s) play important roles in implantation. Depletion of CD11b+ pan-M s in CD11b-diphtheria-toxin-receptor (DTR) mice is reported to cause implantation failure due to decreased progesterone production in the corpus luteum. However, of the M1 and M2, the type of M s that is ...
The intratumoral and peritumoral densities of CD163-positive macrophages were defined as intratumoral and peritumoral M2-like TAM densities and determined as the number of cells per mm2. The Ki-67 proliferation index was determined by scoring the percentage of carcinoma cells with positive staining...