在巨噬细胞中,其被称为macrophage-derived extracellular vesicles(Mp-EV)。它们在 TME 内的不同细胞之间运输各种生物活性物质,包括蛋白质、代谢物和核酸(DNA、mRNA、lncRNA、miRNA)。肿瘤来源的外泌体可以诱导基质细胞分化为肿瘤相关细胞,将抗肿瘤环境转变为促肿瘤环境,并可以通过触发 EMT 来赋予肿瘤耐药性并促进...
These events led to the modulation of M2 polarization of macrophages, which eventually contributed to the alleviation of pulmonary fibrosis. Our results revealed a novel mechanism that may account for therapeutic effect of microcystin-LR on IPF....
论文原文: Liu, T., Wang, L., Liang, P. et al. USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy. Cell Mol Immunol 18, 2431–2442 (2021). https:...
从机制上讲,BPIFB1 在体外和体内均作为 M2巨噬细胞极化的激活剂并促进肿瘤转移。研究成果发表在 Cancer Science 期刊题为“BPIFB1 promotes metastasis of hormone receptor-positive breast cancer via inducing macrophage M2-like polarization”。 首先,研究人员收集了癌症基因组图谱(TCGA)的 RNA 测序表达谱和临床...
[2] Wan X, Xie B, Sun H, et al. Exosomes derived from M2 type tumor-associated macrophage promoteosimertinib resistance in non-small cell lung cancer through MSTRG.292666.16-miR-6836-5p-MAPK8IP3 axis[J]. Cancer Cell Int, 2022, 22(1):...
Beiging of white adipose tissue (WAT) is associated with an increase of anti-inflammatory M2-like macrophages in WAT. However, mechanisms through which M2-like macrophages affect beiging are incompletely understood. Here, we show that the macrophage cytokine Slit3 is secreted by adipose tissue macro...
the well-characterized M2-like macrophage markers CD163, and MgL2. We determined that the F4/80 + CD206 − population expressed higher level of CD11c, TNFα, IL-6, Zbtb46 mRNA (Fig. 1b, red) than the F4/80 + CD206 + population, indicating that the former includes substantial amount...
PURPOSE The objective of the present study was to characterize and compare the macrophage phenotype elicited by the ZFuze polymer, PEEK, titanium-based alloys, or iterations of modified ZFuze polymer. The ability of these materials to promote differentiation of osteoblast-like cells in vitro was ...
肿瘤相关巨噬细胞:(Tumor-associated macrophages,TAMs)是属于巨噬细胞细胞系的一种细胞,发现于肿瘤组织附近。TAM由淋巴循环中的单核细胞或组织中残留的巨噬细胞衍生而来,是浸润许多种肿瘤基质的白细胞的主要类型。 本文提及的M2-like tumor-associated macrophage如下简称为M2-TAM...
总之,EC利用糖酵解作用使血管内分泌乳酸分泌,从而引导肌肉从缺血中再生。 据悉,EC来源的信号有助于器官再生,但血管分泌代谢产生的交流尚不了解。 原文标题: Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization...