There is a wide range of symptoms, severity, and other manifestations of these disorders. The expression of autism spectrum disorders varies widely among affected individuals. A child with significant impairment in all three of the core functioning areas (socialization, communication, and atypical, rep...
To profile early neurodevelopmental alterations in ASD with macrocephaly, we monitored subject-derived induced pluripotent stem cells (iPSCs) throughout the recapitulation of cortical development. Our analysis revealed ASD-associated changes in the maturational sequence of early neuron development, involving ...
The age of onset of migraine headaches is earlier in boys than in girls. From infancy to 7 years of age, boys are affected equally or slightly more than girls. The prevalence of migraines increases during the adolescent and young adult years. After menarche (the time when the firstmenstrual ...
Neurofibromatosis type 1 (NF1) Neurofibromas, multiple café-au-lait spots, axillary and inguinal freckling, iris hamartomas (Lisch nodules), bony abnormalities, central nervous system gliomas, macrocephaly, and cognitive deficits SDHx mutation Paraganglioma and/or Pheochromocytoma, pituitary tumor, gastr...