Sloane BF. Rozhin J. Ryan RE, Lah TI',Day NA, Crissman JD. Honn KV. Cathepsin B-like cysteine proteinase and metastasis. In Honn KV. Powers WE. Sloan BF. Mechanisms of Cancer Metastasis. Boston: Martinus Nijhoff Publ, 1986.Sloane BF, Rozhin J, Ryan RE, Tamara TL, Day NA, ...
Cathepsin B-like cysteine proteinase- deficient mutants of Leishmania mexicana. Mol Biochem Parasitol 1997; 88: 53–61. 25. Zangger H, Mottram JC, Fasel N. Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis? Cell Death Differ 2002; 9: 1126–1139...
Cathepsin B is a lysosomal cysteine protease that is secreted as a 42-kDa inactive precursor and then converted by a series of proteases like cathepsin D, uPA and tPA into various active fragments of 31–33-kDa single chain or 26–24-kDa double chain forms [14]. ...
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidas...
L. Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans. DNA Cell Biol. 15, 75–82 (1996) Article CAS PubMed Google Scholar Lorimore, S. A., Rastogi, S., Mukherjee, D., Coates, P. J. & Wright,...
We studied the relationship between cathepsin B (CB)-like enzyme activities and cysteine proteinase inhibitor (CPI) activities in lesions of human pigmented naevi (PN), primary melanomas (PM) and metastases/metastatic melanomas (MM). The CB-like enzyme activities in PM and MM were 2.5 and 6.8...
In the same fluids, two kinds of cysteine-proteinase inhibitors (C.P.I.'s) are found- HMr-CPI (90,000 daltons) and LMr-CPI's (11,000-13,000 daltons). The Cathepsin B-like enzyme is more strongly inhibited by the LMr-CPI's than by the HMr-CPI, the Ki values are 4.0 X 10(-...
A possible role for cysteine proteinase and its inhibitors in motility of malignant melanoma and other tumour cells 1992, Melanoma Research Cysteine proteinases produced by cultured rabbit V2 carcinoma cells and rabbit skin fibroblasts 1986, International Journal of Cancer Integrity of glycoprotein complex...
, 2012b). Cysteine cathepsins belong to the clan CA of cysteine peptidases, more specifically to the C1 family of papain-like enzymes, the largest and, in addition to the aspartic cathepsin D, the most studied group of lysosomal proteases. Cysteine cathepsins are predominantly endopeptidases (...