et al. HLA-B*1502 strongly predicts carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Thai patients with neuropathic pain. Pain Pract12, 202-8 (2012).Kulkantrakom K, Tassaneeyakul W, Tiamkao S, et al. HLA-B1502 strongly predicts carbamazepine-induced Stevens-...
Screening for the HLA-B*1502 allele before prescribing carbamazepine is less costly than the treatment of carbamazepine-induced Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) in Thailand. This is the main finding of a study that compared the cost of HLA-B*1502 screening to ...
strong association between HLA-B*1502 and carbamazepine-indeced SJS and TEN have been found in Chinese Han population,but not in Caucasian.Ethinicity might be a risk factor.Carbamazepine is prescribed in clinical work currently,the objective of this study is to review accociation HLA-B*1502 ...
Conclusions: CBZ- and PHT-induced SJS, but not MPE, is associated with HLA-B*1502 allele in Thai population. 展开 关键词: HLA‐B*1502 Carbamazepine Phenytoin Stevens‐Johnson syndrome Maculopapular eruption Thai DOI: 10.1111/j.1528-1167.2008.01719.x ...
SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE SERIOUS AND SOMETIMES FATAL DERMATOLOGIC REACTIONS, INCLUDING TOXIC EPIDERMAL NECROLYSIS (TEN) AND STEVENS-JOHNSON SYNDROME (SJS), HAVE BEEN REPORTED DURING TREATMENT WITH CARBAMAZEPINE. THESE REACTIONS ARE ESTIMATED TO OCCUR IN 1 TO 6 PER 10,000 ...
Carbamazepine should not be used in patients positive for HLA-B*1502 unless the benefits clearly outweigh the risks. Tested patients who are found to be negative for the allele are thought to have a low risk of SJS/TEN (see BOXED WARNINGand PRECAUTIONS, Laboratory Tests). Over 90% of ...
摘要: Purpose The purpose of this study is to examine the association of HLA-B*1502 allele with CBZ-induced SJS/TEN in the mainland Han Chinese population.关键词: HLA-B*1502 – Carbamazepine – Stevens-Johnson syndrome – Toxic epidermal necrolysis – Mainland Chinese ...
Rajappa, S.M.Elsevier B.V.Journal of the Neurological SciencesVenkatesan SA, Rajappa SM. HLA-B*1502 genotyping in carbamazepine induced Stevens Johnson's syndrome and toxic epidermal necrolysis. Vienna, Austria. J Neurol Sci 2013;333:e62....
(PCR-SSP) method in 19 Han subjects who had carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis,90 carbamazepine tolerant controls,and 80 healthy individuals.Results:The frequency of HLA-B*1502 allele in SJS/TEN patients was significantly higher than that in carbamazepine-...
Retrospective case-control studies have found that in patients of Chinese ancestry there is a strong association between the risk of developing SJS/TEN with carbamazepine treatment and the presence of an inherited variant of the HLA-B gene, HLA-B*1502. The occurrence of higher rates of these re...