Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients. Yan Zhang,Jin Wang,Li-Mei Zhao. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY . 2011Zhang Y, Wang J, Zhao LM, et al. Strong association between HLA...
Screening for the HLA-B*1502 allele before prescribing carbamazepine is less costly than the treatment of carbamazepine-induced Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) in Thailand. This is the main finding of a study that compared the cost of HLA-B*1502 screening to ...
HLA-B*1502 is largely absent in individuals not of Asian origin (e.g., Caucasians, African-Americans, Hispanics, and Native Americans). Prior to initiating carbamazepine therapy, testing for HLA-B*1502 should be performed in patients with ancestry in populations in which HLA-B*1502 may be pr...
Pharmacogenetic testing for the variant HLA-B*1502 allele is recommended in patients who may be at increased risk of carbamazepine-induced SJS and TEN. (See Boxed Warning.) Prior to initiating carbamazepine therapy, screen patients in genetically at-risk populations for HLA-B*1502. High-resolution...
Serious and sometimes fatal dermatologic reactions, including toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), have been reported, especially in patients with the inherited allelic variant HLA-B*1502 who are almost exclusively of Asian ancestry. Avoid use of carbamazepine in patient...
摘要: Purpose The purpose of this study is to examine the association of HLA-B*1502 allele with CBZ-induced SJS/TEN in the mainland Han Chinese population.关键词: HLA-B*1502 – Carbamazepine – Stevens-Johnson syndrome – Toxic epidermal necrolysis – Mainland Chinese ...
In addition, no association between HLA-B alleles and CBZ- or PHT-induced MPE was found. Conclusions: CBZ- and PHT-induced SJS, but not MPE, is associated with HLA-B*1502 allele in Thai population. 展开 关键词: HLA‐B*1502 Carbamazepine Phenytoin Stevens‐Johnson syndrome Maculopapular ...
Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan — NEJM The identification of subjects carrying the HLA-B*1502 allele and the avoidance of carbamazepine therapy in these subjects was strongly associated with a decrease in the incidence of carbamazepine-induced SJS–TEN. (...
The purpose of this study is to examine the association of HLA-B*1502 allele with CBZ-induced SJS/TEN in the mainland Han Chinese population. HLA-B*1502 ge
Common side effects of carbamazepine include dizziness, drowsiness, nausea, vomiting and ataxia. It carries a black box warning for severe dermatologic reactions, particularly in Han Chinese with the HLA-B*1502 gene, increasing the risk of SJS/TEN. HLA-B*4001, HLA-B*4601, and HLA-B*5801 ar...