et al. HLA-B*1502 strongly predicts carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Thai patients with neuropathic pain. Pain Pract12, 202-8 (2012).Kulkantrakom K, Tassaneeyakul W, Tiamkao S, et al. HLA-B1502 strongly predicts carbamazepine-induced Stevens-...
HLA-B*1502, AN INHERITED ALLELIC VARIANT OF THE HLA-B GENE. HLA-B*1502 IS FOUND ALMOST EXCLUSIVELY IN PATIENTS WITH ANCESTRY ACROSS BROAD AREAS OF ASIA. PATIENTS WITH ANCESTRY IN GENETICALLY AT-RISK POPULATIONS SHOULD BE SCREENED FOR THE PRESENCE OF HLA-B*1502 PRIOR TO INITIATING TREATMENT ...
Screening for the HLA-B*1502 allele before prescribing carbamazepine is less costly than the treatment of carbamazepine-induced Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) in Thailand. This is the main finding of a study that compared the cost of HLA-B*1502 screening to ...
Pharmacogenetic testing for the variant HLA-B*1502 allele is recommended in patients who may be at increased risk of carbamazepine-induced SJS and TEN. (See Boxed Warning.) Prior to initiating carbamazepine therapy, screen patients in genetically at-risk populations for HLA-B*1502. High-resolution...
Serious and sometimes fatal dermatologic reactions, including toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), have been reported, especially in patients with the inherited allelic variant HLA-B*1502 who are almost exclusively of Asian ancestry. Avoid use of carbamazepine in patient...
It carries a black box warning for severe dermatologic reactions, particularly in Han Chinese with the HLA-B*1502 gene, increasing the risk of SJS/TEN. HLA-B*4001, HLA-B*4601, and HLA-B*5801 are protective alleles. Aged patients are at risk of delirium due to its mild anticholinergic ...
strong association between HLA-B*1502 and carbamazepine-indeced SJS and TEN have been found in Chinese Han population,but not in Caucasian.Ethinicity might be a risk factor.Carbamazepine is prescribed in clinical work currently,the objective of this study is to review accociation HLA-B*1502 ...
and diarrhea have been reported.Hyponatremia(low plasma sodium concentration) is also reported.Hypersensitivity reactions(e.g., blood, liver, or skin disorders) may occur rarely. There is a risk of Stevens–Johnson syndrome in presence of HLA-B∗1502 allele, which is more prevalent in individua...
In addition, no association between HLA-B alleles and CBZ- or PHT-induced MPE was found. Conclusions: CBZ- and PHT-induced SJS, but not MPE, is associated with HLA-B*1502 allele in Thai population. 展开 关键词: HLA‐B*1502 Carbamazepine Phenytoin Stevens‐Johnson syndrome Maculopapular ...
HLA-B1502 (risk of life threatening skin reactions) See contraindications above Indicated before starting in asian and indian patients HLA-B3101 may also be associated with similar skin reactions Serum Carbamazepine level Initial: Every 1-2 weeks ...