Adipocytes change into CAAs in the invasive front of breast cancer. Normally, mature adipocytes and epithelial cells are separated by the basement membrane, limiting the possibility of interaction between both cell types. However, BC cells will directly expose to the TME containing adipocytes when BC...
Bochet, L (2011) Cancer-associated adipocytes promotes breast tumor radioresistance. Biochemical and Biophysical Research Communications 411: pp. 102-106Bochet L, Meulle A, Imbert S, Salles B, Valet P, Muller C. Cancer-associated adipocytes promotes breast tumor radio- resistance. Biochem Biophys ...
Cancer-associated adipocytes (CAAs), one of the primary stromal components, exhibit intimate crosstalk and release multiple cell factors mediating local and systemic biological effects. However, the role of CAAs in the regulation of systemic immune responses and their potential value in the clinical tr...
Breast cancer (BC) is a malignant breast tumor confronted with high invasion, metastasis and recurrence rate, and adipocytes are the largest components in breast tissue. The aberrant adipocytes, especially the BC-neighbored cancer-associated adipocytes (CAAs), are found in the invasive front of BC...
Cancer-associated adipocytes (CAAs) have been suggested to promote tumor progression. Yet, the role of CAAs in triple-negative breast cancer (TNBC) is poorly investigated. We compared the expression of secretory protein-encodin...
Early local tumor invasion in breast cancer results in a likely encounter between cancer cells and mature adipocytes, but the role of these fat cells in tumor progression remains unclear. We show that murine and human tumor cells cocultivated with mature adipocytes exhibit increased invasive capacitie...
Cancer-associated adipocytes are known to cause inflammation; however, the role of adipogenesis, the formation of adipocytes, in breast cancer is unclear. We hypothesized that intra-tumoral adipogenesis reflects a different cancer biology than abundance of intra-tumoral adipocytes. The Molecular Signatures...
Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res. 2011;717:2455–65. Article CAS Google Scholar Rhim AD, et al. EMT and dissemination precede pancreatic tumor formation. Cell. 2012;1481–2:349–61. Article CAS Google Scholar ...
Cancer-associated fibroblasts (CAFs) play key roles in tumor microenvironment; they are thought to originate from adipocytes. This study aimed to evaluate CAF-related protein expression and its implications in breast cancer. Of the 939 enrolled breast cancer patients, 642 had fibrous and 297 had ad...
PD-L1 PD-1 Cancer-associated adipocytes; DCs Promote browning and inflammation Induce lipidolysis and suppress lipogenesis 6,91,92 B7-H3 TLT-2 Progenitors; fibroblasts; immune cells Control adipogenesis and regulates adipocyte differentiation 105,106 VSIG4 C3b; iC3b Macrophage Strongly correlated wit...