Cancer-associated adipocytes (CAAs), one of the primary stromal components, exhibit intimate crosstalk and release multiple cell factors mediating local and systemic biological effects. However, the role of CAAs in the regulation of systemic immune responses and their potential value in the clinical tr...
Intra-tumoral adipocytes, also known as cancer-associated adipocytes, interact with cancer cells and secrete the inflammatory cytokines (e.g.: IL-6 and TNF-α)7. These cytokines contribute to pro-cancer inflammation, which is known to aggravate cancer progression, and activate several pathways, su...
. As explained below, stressed cancer cells rely on FAO to produce ATP for survival or NADPH for redox homeostasis to counter high oxidative stress levels in these cells. Mitochondrial dysfunction has also been associated with antiapoptotic cancer cell phenotypes [116]. Support for this association ...
22,23]. The desmoplastic reaction is widely regarded as a hallmark of PDAC, more importantly, it’s shown to be predominantly responsible for intercellular signaling and TME reprogramming [23] (Fig.1). However, the contribution of TME-associated desmoplasia...
Transition into inflammatory cancer-associated adipocytes in breast cancer microenvironment requires microRNA regulatory mechanism PLoS One, 12 (3) (2017) e0174126 Google Scholar [13] J. Han, et al. Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and br...
Keywords adipocytes adipokines adiposity metabolic dysregulation white adipose tissue Search within this book Search Table of contents (9 chapters)Front Matter Pages i-viii Download chapter PDF Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity–Cancer Link Nikki A...
Cancer-associated fibroblasts (CAFs) are the most abundant stromal cells within the tumor microenvironment (TME). They extensively communicate with the other cells. Exosome-packed bioactive molecules derived from CAFs can reshape the TME by interacting w
MSCs are multipotent cells, which can self-renew and differentiate into adipocytes, cartilage, bone, and other cells under the appropriate conditions [32]. MSCs can be recruited to the stroma of HCC and play an essential role in HCC initiation, progression [33]. MSCs infiltrating the TME can...
Adipose tissue, which is mainly composed of adipocytes, is a crucial component of the tumor microenvironment, particularly in breast cancer. Adipocytes surround breast cancer cells and may participate in cell‒... Authors: Jinna Wu, Jia Li, Huiya Xu, Ni Qiu, Xiaojia Huang and Hongsheng Li...
In the tumor microenvironment, adipocytes function as an alternate fuel source for cancer cells. However, whether adipocytes influence macromolecular biosynthesis in cancer cells is unknown. Here we systematically characterized the bidirectional interaction between primary human adipocytes and ovarian cancer (...