Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before...
Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before...
Cholesterol homeostasis is essential for healthy mammalian cells and dysregulation of cholesterol metabolism contributes to the pathogenesis of various diseases including cancer. Cancer cells are dependent on cholesterol. Malignant progression is associated with high cellular demand for cholesterol, and extracell...
However, if we analyze the definition of obesity of the WHO, which identifies it as “a condition in which percentage body fat (PBF) is increased to an extent in which health and well-being are impaired”, we can state that it is defined by the expansion of the adipose tissue, rather ...
The machinery and regulation of autophagy were outlined with special attention to its role in diabetes, neurodegenerative disorders, in- fectious diseases and cancer. Keywords: autophagy; disease; physiology What is autophagy? Macroautophagy (referred to hereafter as autophagy) is a genetically ...
Obesity-associated IR is linked to increased hepatic glucose output and reduced glucose disposal for a given amount of insulin [9] and is associated with not only the total quantity of adipose tissue, but mainly its distribution and more specifically with the degree of ectopic fat distribution [...
DDT is a well-known pesticide that was banned in the United States in 1972 because of its cancer-causing properties. Yet even after decades, DDT is regularly found in the fatty tissue of animals, birds, fish, and children. In this particular study, the researchers found that nursing was ...
What is the number 1 worst carb? 14 Foods to Avoid (Or Limit) on a Low-Carb Diet Bread and grains. Bread is a staple food in many cultures. ... Some fruit. A high intake of fruits and vegetables has consistently been linked to a lower risk of cancer and heart disease ( 5 , 6...
TNF-α expression is elevated in the adipose tissue of obese rodents and humans. In animal studies, administration of exogenous TNF-α induced insulin resistance, whereas neutral- ization of TNF-α improved insulin sensitivity. TNF-α knock- out mice were used to examine the role of TNF-α ...
and human diseases. The goal of the reviews in the current issue is to provide a general overview of current knowledge on autophagy. The machinery and regulation of autophagy were outlined with special attention to its role in diabetes, neurodegenerative disorders, infectious diseases and cancer. ...