Using multiple datasets from real-world evidence and completed trials, a machine learning model using routine blood and clinical data is shown to be predictive of patient response to immune checkpoint inhibitor therapy, across cancer types and outperforming standard biomarkers. ...
Given prior knowledge of cancer-types/subtypes, CoMEt analyzes alterations and subtypes simultaneously, allowing the discovery of mutually exclusive alterations across cancer types, while avoiding the identification of spurious mutually exclusive sets of (sub)type-specfic mutations. We demonstrate that CoMEt...
More recent studies from a number of groups have identified distinct subtypes of bladder cancer based on mutations and transcriptional profiles that cluster with the luminal and Basal tumor types in MIBC. Approximately 47% of the cases are of the luminal subtype and 35% are of the Basal subtype...
5. Wilson, W.H., Wright, G.W., Huang, D.W., Hodkinson, B., Balasubramanian, S., Fan, Y., Vermeulen, J., Shreeve, M., and Staudt, L.M. (2021). Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL....
Since then, NGS has revolutionized the field of precision oncology, improving cancer detection, prevention, and treatment. This technique can be used to characterize tumor types, screen hereditary cancer, identify appropriate therapeutic agents, and indicate disease prognosis. This chapter reviews NGS-...
They found that some types were defined by their anatomic location and other cancers from the same organ system, such as gastric, colon and rectal cancers, also shared molecular similarities. However, some organ sites had a broad diversity in molecular subtypes, such as the kidney. ...
subtypes of RCC. Interestingly, XIAP was significantly decreased in RCC (Fig.3); increased XIAP expression in ccRCC tumors is significantly associated with better ccRCC patient survival (Fig.4A), while there is no significant difference for chRCC and pRCC patients’ survival with XIAP expression ...
Page 1 of 20 (page number not for citation purposes) BMC Cancer 2007, 7:55 http://www.biomedcentral.com/1471-2407/7/55 Background Invasive ductal (IDC) and lobular carcinomas (ILC) are the most common histological types of breast cancer [1,2]. The terminology of ductal and lobular ...
The cancer stem cell (CSC) model suggests the presence of two functional cell types in a tumor: CSCs and non-CSCs. The first type is a highly tumorigenic subpopulation with stem-like functional features: self-renewal capacity and differentiation potential. Similar to normal stem cells (SCs), ...
spatial distribution characteristics of CAFs and further dissect the cellular communication between CAFs and TME. In this study, we have delineated the landscape of CAFs in six common cancer types and described the unique functional features of these subtypes. We also analyzed scRNA-seq data of ...