Pancreatic cancer is one of the worst prognostic cancers because of the late diagnosis and the absence of effective treatment. Within all subtypes of this disease, ductal adenocarcinoma has the shortest survival
A. et al. Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nature Genet. 47, 1168–1178 (2015) Google Scholar Cerami, E. et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data...
Histopathological criteria do not adequately inform treatment decisions for pancreatic cancer. A molecular taxonomy could improve outcomes with current treatments and accelerate therapeutic development through better patient selection. Emerging molecular taxonomies define biological differences between subtypes that a...
编者按:近日,Molecular Cancer杂志(中科院1区,即时IF=32)在线发表了中国医学科学院肿瘤医院赵宏教授团队的研究成果(论文题目:Comprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenviro...
Molecular Subtypes of Breast Cancer: An Insight into the Disparity in Breast Cancer Outcomes Breast Diseases: A Year Book Quarterly Volume 19, Issue 2,July–September 2008, Pages 126-128 Purchase options CorporateFor R&D professionals working in corporate organizations. ...
Finally, they achieved 70% accuracy in the classification of the four subtypes. Wu et al. [35] proposed a complete “white box” machine learning method to predict the molecular subtypes of breast cancer. They used a highly interpretable decision tree as the backbone model, and finally achieved...
In 2014, breast cancer remains a major cause of mortality worldwide mostly due to tumor relapse and metastasis. There is currently a great interest in identifying cancer biomarkers and signalling pathways mechanistically related to breast cancer progress
of undergoing dramatic remodelling, in terms of both architecture and function, in response to pathological conditions such as inflammation or cancer [3]. Many solid cancers spread through the lymphatic system to distant organs, with the LNs typically serving as a first site of seeding outside ...
Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression
Molecular Subtypes and Mechanisms of Breast Cancer: Precision Medicine Approaches for Targeted Therapies 乳腺癌的分子亚型和机制:靶向治疗的精准医学方法 网址 https://doi.org/10.3390/cancers17071102 DOI 10.3390/cancers17071102 复制 doi 其它 期刊:Cancers 作者:Eduarda Carvalho; Sule Canberk; Fernando ...