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Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tum...
A panel of 32 candidate reference genes was used to identify the most stable genes for gene normalisation in quantitative RT-PCR studies using endometrial biopsies obtained from women with endometrial cancer (type 1 or type 2) and without cancer (controls). RNA from the biopsies was isolated, ...
SAN FRANCISCO, June 17 (Xinhua) -- A study by U.S. researchers says people who develop Type 2 diabetes after 60 are more likely to develop pancreatic cancer. The new study by the Keck School of Medicine of the University of Southern California (USC) was published in the Journal of the ...
The effects of Tai Chi on balance and peripheral somatosensation in older adults with type 2 diabetes The increasing prevalence of type 2 diabetes in older adults is a major health concern, as older adults with diabetes have a two- to threefold risk of injurious falls and physical disability....
"As the incidence of diabetes continues to rise, the cancer rate will likely increase, as well," Termini said. Scientists have suspected that the elevated cancer risk for diabetics arises from hormonal dysregulation. "In people with type 2 diabetes, their insulin is not effectively carrying glucos...
(cDC1s), and classical type 2 dendritic cells (cDC2s), and T cells into CD4 + T cells, CD8 + T cells, and Tregs, and conducted CellChat analysis between iCAFs and immune cells (Figure S19f-i). Notably, we found anti-PD1 treatment enhanced iCAFs' ability to promote the ...
As an internationally recognized journal, Molecular Cancer is dedicated to the innovation of how basic cancer research drives advances in cancer prevention, ...
While we previously found TP53 mutations in the L2/L3 domains to be associated with drug resistance, some tumors harboring wild-type TP53 were also therapy resistant. The aim of this study was; 1) To explore alterations in the TP53 gene with respect to resistance to a regular dose epirubicin...
The edges indicated the type of interaction. Only drugs with inhibitory effects were used to construct the network. Structural modeling and molecular docking In this study we employed molecular docking to investigate the binding interactions of TTK kinase with three drugs: BAY-1161909 (Bay-11), ...