CancerTYPE ID uses real-time RT-PCR to measure the expression of 92-genes in the patient's tumor and classifies the tumor by matching the gene expression pattern to a database of over 2,000 known tumor types and subtypes. Using this technology, CancerTYPE ID can differentiate between 50 di...
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous and aggressive type of T-cell lymphoma. Here, the authors perform single-cell analyses of human and murine PTCL-NOS tumors, and identify a subtype defined by the loss of SMARCB1 that could be targeted with HDAC...
Cancer cell lines were seeded on rat-tail collagen type I-coated (200 μg ml−1) 96-well Imagelock plates (Sartorius) at approximately 90% confluence in cell culture medium containing rat-tail collagen type I (1 mg ml−1). A wound was scratched in the cell monolayer across...
EpCAM is a type I epithelial transmembrane glycoprotein and a homophilic Ca2 + -independent cell–cell adhesion molecule [94]. EpCAM exhibits a broad functional spectrum in multiple physiological, developmental, and pathological processes [95]. It contributes to the homeostatic maintenance of epit...
type C57BL/6 (CC), C3H/HeN (HH) and reciprocal MNX mice C57BL/6 nDNA:C3H/HeN mtDNA (CH) and C3H/HeN nDNA:C57BL/6 mtDNA (HC) into which cells were injected either orthotopically or into the lateral tail vein. Critically, wild-type mice and their nuclear-matched MNX counterparts...
This gene encodes a myosin light polypeptide kinase containing 1 fibronectin type-III domain. Genes encoding proteins involved in ion and electron transport (CYB5R2, GABRP), and genes encoding proteins with transcription factor and regulator activity (ELF5, ID4) were downregu- lated in both ...
Periodical cited type(17) 1. Liang, N., Li, Z., Sun, J. et al. A systematic review on heavy metals in indoor air: Occurrence, spatial variation, and health risk. Building and Environment, 2025, 269: 112357. DOI:10.1016/j.buildenv.2024.112357 2. Chen, Z., Cheng, X., Wang, X...
(ITH) to infer tumour phylogeny2,3,4. However, previous studies that used multiregion sequencing of primary tumour samples, herein referred to as ‘regions’, have been limited to 100 patients or fewer for a given tumour type, which limits statistical power for genomic and clinical analyses5....
Signatures were extracted from each type of cancer individually, from all cancer types together, as separate SBS, DBS and indel signatures, and as composite signatures of all three types of mutation (Supplementary Note 2). We used two methods based on nonnegative matrix factorization (NMF): ...
Besides, the percentage of a certain type (type x) of immune cells were calculated with following formula: $${P}_{tumor\, infiltrating\, immune\, cells \,x}=\frac{{n}_{x}}{{n}_{\mathrm{nontumorous}}}$$ In vitro proof of concept for bioinformatic analyses Cell culture Human ...