Colorectal cancer (CRC) is one of the most frequently diagnosed types of cancer worldwide, ranking third in terms of tumour incidence and second in cancer mortality1. The gut microbiome has been associated with molecular mechanisms underlying CRC initiation, progression and treatment. Isolated gut mi...
we extracted the top 3% most differentially expressed gene sets from each cancer type and calculated the number of common DE gene sets between cancer types. The results are shown in the upper triangular matrix inTable 1. We
(PDQ)—Health Professional Versionhttps://www.cancer.gov/types/colorectal/hp/colorectal-screening-pdq Colorectal Cancer Screening Testshttps://www.cdc.gov/cancer/colorectal/basic_info/screening/tests.htm The Community Preventive Services Task Force has also issued recommendations on interventions to ...
Among various cancer types, including UVM and SKCM, we observed a positive correlation between the expression of A3B and RNASEH1, a well-established nuclease that resolves R-loops [27] (Fig. S2). By analyzing the R-loop interactors from previous reports [28,29], we noticed the involvement...
Both innate (myeloid) and adaptive (lymphoid) leucocyte types have been demonstrated as breast cancer modifiers [14]. Doubtless cytotoxic T-lymphocytes have a function in constraining tumour developments that is evident, in particular, for the tumours of viral origin [15]. On the other side, ...
and d) curated/published gene signatures in new version. Users can now also adjust the survival analysis models for available covariates. Users can study prognostic implications of entire gene signatures in different cancer types, which are searchable by keywords. Also, unique to our tool, in the...
and cancervaccination. These strategies are currently being tested acrosscancer typesthat vary in their cancerimmunogenicity, which likely reflects quantitativeneoantigenburden as well as qualitative properties such asantigen bindingtoHLA, the nature of T-cell recognition of these antigen/HLA complexes, and...
In recent years, the application of single-cell transcriptomics has unraveled the heterogeneity of CAFs within many cancer types, such as bladder carcinoma (BC) [6], head and neck squamous cell carcinoma (HNSCC) [7], papillary thyroid carcinoma (PTC) [8], and lung cancer (LC) [9]. Furth...
The CIBERSORT estimates were based on molecular signatures of most, but not all, cell types that comprise the human breast; we did not have data for mammary basal epithelial cells and the data for adipocytes was derived from subcutaneous abdominal adipose tissue rather than from breast adipose ...
Third, two types of heterogeneity were observed in ERBB2-amplified BCs. The genomic profiles of estrogen receptor-postive (ER+) and negative (ER-) ERBB2-amplified BCs were different. The WNT/β-catenin signaling pathway was involved in ER- ERBB2-amplified BCs, and PVT1 and TRPS1 were ...