In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic pontine glioma, repeated intracranial infusions were feasible and well tolerated with a median overall survival of 19.8 months and 3 patients...
Pancreatic ductal adenocarcinoma (PDAC) is the type of pancreatic malignancy with the highest prevalence, predicted to become the second deadly tumor by 2030 [9,10,11]. It is a heterogeneous disease with a 5-year survival rate around 13%, due to late diagnosis, associated with the most recur...
For survival rate, we performed a survival analysis for the expression profiles of each driver gene, like in refs.49,50,51,52,53. In brief, given a driver gene, the median expression of that gene was calculated across the patients, then the patients were classified into two groups based o...
The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) dataset was utilized for gene expression correlation analysis, survival analysis, and enrichment analysis, and the results were then validated with the GSE14520 dataset obtained from the Gene Expression Omnibus (GEO). The list of genes...
https://www.cancercareontario.ca/en/find-cancer-services/regional-cancer-centres/list. Accessed Oct. 23, 2022 Robles SC, Marrett LD, Clarke EA, Risch HA. An application of capture-recapture methods to the estimation of completeness of cancer registration. J Clin Epidemiol. 1988;41(5):495–...
The Kaplan-Meier method was used to calculate the cumulative survival rate, which was then stratified by gender and by period (1994–1999 versus 2000–2004). The clinico-pathological variables that might affect CRC survival were analyzed by Cox regression analysis. Results Between 1994 and 2004, ...
Current evidence suggests that breast cancer (BC) accounted for 11.7% of all cancer types in 2020, surpassing lung cancer as the most prevalent cancer [172]. Recent advances in therapeutic approaches have improved BC patient survival and quality of life, but mortality rates remain high due to ...
(10 mg/kg) every two weeks. The primary endpoint was safety, while secondary endpoints included objective response rate (ORR), overall survival (OS), progression-free survival (PFS), and duration of response (DoR), among others. As of February 7, 2023, the combination therapy of serplulim...
Cancer cells can develop dependencies on amino acids produced and secreted by CAFs to fuel their growth23,24,25,50. For example, tumour collagen-derived proline promotes PDAC cell survival under nutrient-limited conditions25. Here we establish that proline is also important to support the CAF ...
The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progression. Herein, we investigated the impact of 32 Hippo genes on overall survival (OS) of cancer patients, by both analysing data from The Cancer Genome Atlas (TCGA) and reviewing the related lite...