Clinical trials and future potential of targeted therapy for ovarian cancer. Int J ClinOncol. 2012 Aug 28;17(5):430-40.Itamochi H, Kigawa J (2012). Clinical trials and future potential of targeted therapy for ovarian cancer. Int J Clin Oncol, 17, 430-40....
“Targeted therapy” is all the buzz in oncology circles lately. Targeting tumors at cellular levels creates more effective therapies—often with fewer side effects than traditional treatments—and allows trials to progress more quickly. Reinforcing this trend, the FDA approved several effective new ant...
faster and more economical than inventing a new drug from scratch, as existing drugs have known pharmacokinetics and safety profiles and have often been approved for human use, therefore any newly identified use(s) can be rapidly evaluated in clinical trials [4]. In the last 5 years nic...
These drugs have entered clinical trial stages, with Bavdegalutamide (NCT03888612), ARV-471 (NCT04072952), and NX-2127 (NCT04830137) showing their therapeutic effectiveness; the PROTAC targeting MAP4K1 has the potential to be a “first-in-class” therapy mimicking PD-1/PD-L1 targeted therap...
Nanostructured porous Si-based nanoparticles for targeted drug delivery cell targetingfunctionalizationcancer therapyin vivoin vitrodrug deliveryOne of the backbones in nanomedicine is to deliver drugs specifically to unhealthy cells... MA Shahbazi,B Herranz,HA Santos - 《Biomatter》 被引量: 83发表: ...
References 73 and 74 review the clinical use of 13C-MR spectroscopy as a technique to image metabolism in patients that could considerably aid the development of drugs targeting cancer metabolism. Article CAS Google Scholar Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, ...
This article, provides a comprehensive review of the underlying mechanism of action, representative drugs, corresponding clinical trials, recent advancements, and future research directions pertaining to HER2-targeted therapy.Introduction Human growth factor receptor 2(HER2/erbB2) belongs to the epidermal ...
摘要: To describe the emergence of targeted therapies that have led to significant breakthroughs in cancer therapy and completed or ongoing clinical trials of novel agents for the treatm... 查看全部>>关键词: Targeted therapy Molecular alterations Bioinformatics Precision medicine Big data analysis ...
The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs Article 18 October 2021 Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers Article Open access 17 September 2021 Harnessing TRAIL-induced cell death for cancer therapy: a long walk ...
et al. PTPN11 Is a central node in intrinsic and acquired resistance to targeted cancer drugs. Cell Rep. 12, 1978–1985 (2015). Article CAS PubMed Google Scholar US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT03114319 (2019). US National ...