Several drugs that exhibit potent off-target effects (side effects) in cancer are also worth exploring. These off-target effects can be viewed as new indications of the drug for other diseases (phenotypic analysis).25Phenotypic screening is a strategy that analyzes biology-associated (phenotypic) e...
Cancer cells have modifications in their genes or proteins that make them different from normal cells. Consequently, they can develop faster and sometimes could spread. Targeted cancer therapy works by those differences and targets cancer's specific genes and proteins that contribute to cancer growth ...
differentiation, and migration. The tumor microenvironment, including local blood vessels and immune cells, might also be altered by targeted drugs to impede tumor growth and enact stronger immune surveillance and attack. Small molecules, such as monoclonal antibodies, are major players in targeted the...
Actively targeted drug delivery systems mainly use some specific or highly expressed biomarkers at the tumor site to deliver drugs to specific cells in a targeted manner. The surface of the drug delivery system is modified with specific ligands, such as proteins, antibodies, polypeptides or small c...
Among the many barriers to repurposing cancer drugs, economical-driven are the most important that difficult the clinical development of them. In this review, we provide an overview of the current status of drug repurposing for cancer therapy and the barriers that need to be overcome to realize ...
Moreover the concept of low HER2 expression signifies a breakthrough in HER2-targeted therapy, indicating that an increasing number of tumors and patients will benefit from this approach. This article, provides a comprehensive review of the underlying mechanism of action, representative drugs, ...
Alternatively, they can be used in targeted drug delivery systems to transport drugs directly to tumor cells, minimizing toxicity to healthy cells. In this review, we will discuss the latest and most advanced approaches to using aptamers for cancer treatment, particularly targeted therapy overcoming ...
Targeted treatment focuses on particular targets inside or on cancer cells. These targets play a role in how cancer cells grow and survive. Using these targets the drug disables the cancer cells, so they cannot spread, and on the other side, normal cells can survive.Targeted therapy drugs ...
Several Trop2-targeted drugs are currently under development, including antibodies, ADCs, and combination therapies, with ADCs at the forefront of cancer therapy and precision medicine. The FDA has approved SG for the treatment of TNBC and HR+/HER2-breast cancer patients. There are several Trop2...
In this review, we discussed the different treatment modalities, including small molecule targeted drugs, peptide drugs, antibody drugs, cell therapy, and gene therapy. It will provide a detailed explanation of each method, addressing their status of development, clinical challenges, and potential ...