Several drugs that exhibit potent off-target effects (side effects) in cancer are also worth exploring. These off-target effects can be viewed as new indications of the drug for other diseases (phenotypic analysis).25Phenotypic screening is a strategy that analyzes biology-associated (phenotypic) e...
Cancer cells have modifications in their genes or proteins that make them different from normal cells. Consequently, they can develop faster and sometimes could spread. Targeted cancer therapy works by those differences and targets cancer's specific genes and proteins that contribute to cancer growth ...
Actively targeted drug delivery systems mainly use some specific or highly expressed biomarkers at the tumor site to deliver drugs to specific cells in a targeted manner. The surface of the drug delivery system is modified with specific ligands, such as proteins, antibodies, polypeptides or small c...
In this review, we discussed the different treatment modalities, including small molecule targeted drugs, peptide drugs, antibody drugs, cell therapy, and gene therapy. It will provide a detailed explanation of each method, addressing their status of development, clinical challenges, and potential solu...
Specific targeted therapy offers the hope of improving the treatment of cancer resistant to conventional therapy. A better understanding of the molecular pathogenesis of cancer has contributed to the development of specific novel drugs, including monoclonal antibodies, small molecule inhibitors, mimetic, ...
Among the many barriers to repurposing cancer drugs, economical-driven are the most important that difficult the clinical development of them. In this review, we provide an overview of the current status of drug repurposing for cancer therapy and the barriers that need to be overcome to realize ...
Alternatively, they can be used in targeted drug delivery systems to transport drugs directly to tumor cells, minimizing toxicity to healthy cells. In this review, we will discuss the latest and most advanced approaches to using aptamers for cancer treatment, particularly targeted therapy overcoming ...
Moreover the concept of low HER2 expression signifies a breakthrough in HER2-targeted therapy, indicating that an increasing number of tumors and patients will benefit from this approach. This article, provides a comprehensive review of the underlying mechanism of action, representative drugs, ...
Moreover the concept of low HER2 expression signifies a breakthrough in HER2-targeted therapy, indicating that an increasing number of tumors and patients will benefit from this approach. This article, provides a comprehensive review of the underlying mechanism of action, representative drugs, ...
Several Trop2-targeted drugs are currently under development, including antibodies, ADCs, and combination therapies, with ADCs at the forefront of cancer therapy and precision medicine. The FDA has approved SG for the treatment of TNBC and HR+/HER2-breast cancer patients. There are several Trop2...