Recent advances in understanding the biologic mechanisms underlying cancer development have driven the design of new therapeutic approaches, termed 'targeted therapies', that selectively interfere with molecules or pathways involved in tumor growth and progressio...
Targeted Therapies in Cancer 作者:Dietel, Manfred (EDT) 出版社:Springer Verlag 页数:276 定价:$ 213.57 装帧:HRD ISBN:9783540460909 豆瓣评分 目前无人评价 评价: 推荐 + 加入购书单
Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. ...
amplification or overexpression of the HER2 gene (erbB2). Mutations in HER2 are most commonly observed within the intracellular tyrosine kinase structural domain, encompassing exon 20 (20%), exon 19 (11%) and exon 21 (9%). The mutation hotspot varies across different types of cancer [6]. T...
Abnormal alterations in human epidermal growth factor receptor 2 (HER2, neu, and erbB2) are associated with the development of many tumors. It is currently a crucial treatment for multiple cancers. Advanced in molecular biology and further exploration of
Targeted therapies in the treatment of CRC As a consequence of improved understanding of the molecular pathology of cancer, a number of targeted agents have been developed which have demonstrated improved outcome in metastatic CRC (mCRC) patients, with combination chemotherapy. Among the first of the...
In an age when great advances have been made in understanding the genetics and molecular biology of this heterogeneous disease, it is likely that the introduction of novel targeted therapies will have a major impact on the management of ovarian cancer. Importantly, such strategies might allow ...
Due to the complexity of cancer, effective treatment options in the future will likely require mixing and matching these approaches in different cancer types and different disease stages. 展开 关键词: cancer targeted therapies resistance mechanisms receptor tyrosine kinases single kinase inhibitors ...
Despite the initial promise of cancer therapies targeted against the epidermal growth factor receptor (EGFR), tumors treated with these agents eventually develop resistance. In this Review, the authors outline the complex mechanisms by which tumors becom
In this chapter, we discuss what are the major receptors overexpressed in tumor cells and how these receptors have been widely tested as a targeted therapy in the treatment of cancer. We discuss the main classes of immunotherapy, including monoclonal ant