Intracellular calcium modulates the activity of a number of voltage-dependent ion channels in neurons. This modulation is often functionally important, and can influence the responsiveness of cells to natural inputs. In extreme cases, the regulation of ion channels by intracellular calcium can even ...
The absence of dystrophin in neurons, as well as in skeletal muscle, is associated with an increase in the activity of Ca2+-permeable ion channels. Increased channel activity may be an early event leading to pathophysiological accumulation of intracellular Ca2+ in Duchenne muscular dystrophy. 展开 ...
Calcium channels are ion channels that are triggered to open by either a change in the voltage across the membrane, which occurs in nerve cells propagating a signal, or by small molecule ligands such as inositol 1,4,5-trisphosphate (Ins3P, IP3). Calcium channels allow calcium to flow into ...
Voltage-sensitive Ca channels are among the most heterogeneous of ion channels. In neurons, Ca channels differ in cellular location, biophysical and pharmacological properties, and modulation. A single neuron generally contains multiple types of Ca channels, and such channels are central to the ...
Voltage- and calcium-dependent inactivation of calcium channels in Lymnaea neurons. J. Gen. Physiol. 114, 535–550 (1999). CAS PubMed PubMed Central Google Scholar Ferreira, G., Yi, J., Rios, E. & Shirokov, R. Ion-dependent inactivation of barium current through L-type calcium ...
(GAPs) for inhibition of Ras. RasGRF1, a calcium/CaM-dependent GEF, interacts with the NR2B subunit of NMDAR and mediates activation of the calcium channel and of the Ras/Raf/ERK cascade in hippocampal neurons [54,55]. A novel RasGAP, p135 SynGAP, which is highly abundant at glut...
This review discusses the role of two Ca2+-permeable cation channels, TRPM7 and acid-sensing channels, in glutamate-independent Ca2+toxicity associated with brain ischemia. 展开 关键词: acid-sensing ion channel TRPM7 brain ischemia neurons
7 – Calcium Channels in Mammalian Sympathetic Neurons and PC12 CellsMARK R. PLUMMERPETER HESSDIOMEDES E. LOGOTHETISIon Transport
Calcium-activated chloride channels in the apical region of mouse vomeronasal sensory neurons. J. Gen. Physiol. 140:3-15. http://dx.doi.org/10.1085/ ... Michele,Dibattista,Asma,... - 《Journal of General Physiology》 被引量: 85发表: 2012年 Calcium-activated chloride channels in the apica...
Bean BP. Multiple types of calcium channels in heart muscle and neurons. Modulation by drugs and neurotransmitters. Ann NYAcad Sci 560: 334–345, 1989 PubMed CAS Google Scholar Bean BP. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc Natl ...