Intracellular calcium modulates the activity of a number of voltage-dependent ion channels in neurons. This modulation is often functionally important, and can influence the responsiveness of cells to natural inputs. In extreme cases, the regulation of ion channels by intracellular calcium can even ...
Originally two types of calcium channels were discovered in the somatic membrane of DRG neurons of rat (Vese... PG Kostyuk,YM Shuba,AN Savchenko,... - Springer Berlin Heidelberg 被引量: 8发表: 1988年 337 - Properties of single calcium channels in the neuronal membrane The neurons of snail...
Article 05 August 2024 Structural bases of inhibitory mechanism of CaV1.2 channel inhibitors Article Open access 30 March 2024 Development of phenotypic assays for identifying novel blockers of L-type calcium channels in neurons Article Open access 11 January 2021 References...
Regulating voltage-gated ion channels with nanobodies In this work, Morgenstern and colleagues describe an approach involving functionalized nanobodies which decrease the activity of voltage-gated Ca2+channels associated with β1subunits and promote their removal from the surface membrane of neurons and ...
Functional biology of the α2δ subunits of voltage-gated calcium channels In this review, we examine what is known about the mechanism of action of the auxiliary α 2δ subunits of voltage-gated Ca 2+ (Ca v) channels. First, to p... A Davies,J Hendrich,ATV Minh,... - 《Trends i...
Calcium (Ca2+) signal has become a well-established index for neural activities, as it is essential for the generation of action potentials and synaptic transmissions, which are two fundamental functions of neurons. To control neural Ca2+ signaling with high spatiotemporal precision, optogenetics has...
The effect of noise in the astrocytes on neuronal transmission is investigated numerically based on a random model under both normal and overexpression conditions of metabotropic glutamate receptors on astrocyte membranes. This study suggests that noise could change the firing patterns of two neurons ...
This review discusses the role of two Ca2+-permeable cation channels, TRPM7 and acid-sensing channels, in glutamate-independent Ca2+toxicity associated with brain ischemia. 展开 关键词: acid-sensing ion channel TRPM7 brain ischemia neurons
The detection and processing of painful stimuli in afferent sensory neurons is critically dependent on a wide range of different types of voltage- and ligand-gated ion channels, including sodium, calcium, and TRP channels, to name a few. The functions of these channels include the detection of ...
(GAPs) for inhibition of Ras. RasGRF1, a calcium/CaM-dependent GEF, interacts with the NR2B subunit of NMDAR and mediates activation of the calcium channel and of the Ras/Raf/ERK cascade in hippocampal neurons [54,55]. A novel RasGAP, p135 SynGAP, which is highly abundant at glut...