在该通路中,细胞核内复制压力下产生的DNA片段进入胞浆,通过非经典的cGAS-cGAMP-STING 信号传导过程,内质网上的TRPV2被激活,Ca2+得以释放到胞浆中,从而激活下游CaMKK2/AMPK/EXO1 信号轴,达到保护复制叉和基因组的作用。在后续的工作...
这种不可逆的Ca2+紊乱严重破坏了细胞稳态,包括细胞器层面的线粒体功能障碍和内质网应激以及转录组层面的多个关键的细胞适应性应激反应通路(如MAPK和AMPK通路等)失调。更为重要的是,一系列放疗耐受相关基因的表达量显著下调,提示CAP-P-NO...
Activation of Ca2+-AMPK-mediated autophagy by ginsenoside Rg3 attenuates cellular senescence in human dermal fibroblastsDear Editor, Cellular senescence is a multifaceted process where permanent cell cycle arrest occurs under stresses, indicating the hallmark of aging decline in organisms.1 Ginsenoside Rg3...
的Ca2+通道蛋白打开,Ca2+从溶酶体内流入细胞溶胶,细胞质中的Ca2+浓度升高,激活钙调磷酸酶,钙调磷酸酶催化TFEB-P去磷酸化形成TFEB,TFEB进入细胞核进而促进Atg基因表达,Atg8-PE增多促进自噬维持细胞(和生物体)生命活动;同时Ca2+既可以直接活化AMPK酶,也可以通过先活化CaMKKβ继而激活AMPK,活化的AMPK通过抑制mTOR介导...
AMPK被激活会导致线粒体中葡萄糖的消耗速率增加 2【题目】有丝分裂的分裂期,细胞线粒体中Ca2+浓度突然快速增加,称为“线粒体钙闪”,该过程需要线粒体钙单向转运蛋白(MCU)参与,由内膜两侧的H+浓度梯度提供动力。细胞能量不足时,能量感受器(AMPK)被激活,使MCU磷酸化而活化,促进Ca2+快速转运。Ca2+可以促进有...
在目前的研究中,我们使用CHO细胞系,发现随着GPR40介导的钙的增加,黄连素以剂量依赖性方式活化ERK1/2和AMPK.此外,为了研究黄连素降血糖效果,我们采用腹腔注射葡萄糖和黄连素,发现黄连素较GPR40内源性配体亚油酸更显著的降低血糖浓度.总之,我们的研究可能为黄连素通过GPR40诱导ERK1/2和AMPK磷酸化提供新的药理作用和生理...
目的探讨天麻钩藤饮对自发性高血压大鼠(SHR)血管内皮细胞自噬相关信号通路Ca2+/AMPK/mTOR的影响.方法将30只雄性SHR大鼠随机分为SHR组,尼莫地平组(5.4mg/kg)及天麻钩藤饮组(10.26g/kg),另设京都种大鼠(WKY)作为对照组,灌胃体积为10ml/kg,连续给药6周.采用无创血压仪分别检测各组给药前,给药2周后,给药4周后...
Age and obesity‐associated changes in the expression and activation of components of the AMPK signaling pathway in human right atrial tissue. Exp. Gerontol. 2013; 48:55‐ 63. 37. Kadish ...
Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway Article Open access 30 July 2021 TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate...
The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to other regulatory signals. AMPK activity is absolutely dependent upon phosphorylation of AMPKαThr-172 in its activation loop by one or more AMPK kinases (AMPKKs). The ...