在该通路中,细胞核内复制压力下产生的DNA片段进入胞浆,通过非经典的cGAS-cGAMP-STING 信号传导过程,内质网上的TRPV2被激活,Ca2+得以释放到胞浆中,从而激活下游CaMKK2/AMPK/EXO1 信号轴,达到保护复制叉和基因组的作用。在后续的工作...
CaMKK2/AMPKOxidative stressTelbivudine (LdT), a widely prescribed anti-hepatitis B virus (HBV) drug for the treatment of chronic Hepatitis B (CHB), causes adverse reactions ranging from creatine kinase (CK) elevation to myopathy. The purpose of this study was to explore the mechanism(s) of ...
细胞内溶酶体上的Ca2+通道蛋白打开,Ca2+从溶酶体内流入细胞溶胶,细胞质中的Ca2+浓度升高,激活钙调磷酸酶,钙调磷酸酶催化TFEB-P去磷酸化形成TFEB,TFEB进入细胞核进而促进Atg基因表达,Atg8-PE增多促进自噬维持细胞(和生物体)生命活动;同时Ca2+既可以直接活化AMPK酶,也可以通过先活化CaMKKβ继而激活AMPK,活化的AMPK...
Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CAMKK2) acts as a signaling hub, receiving signals from various regulatory pathways and decoding them via phosphorylation of downstream protein kinases - such as AMPK (AMP-activated protein kinase) and CAMK types I and IV. CAMKK2 relevance is...
Ca(2+)/calmodulin-dependent protein kinase kinase β (CaMKKβ) is a serine/threonine-directed kinase that is activated following increases in intracellular Ca(2+). CaMKKβ activates Ca(2+)/calmodulin-dependent protein kinase I, Ca(2+)/calmodulin-dependent protein kinase IV, and the AMP-depen...
Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway Article Open access 30 July 2021 TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate...
(C) Immunoblot analysis for phospho and total CaMKK-II. n = 6. (D) Hepatocyte lysates from AMPKα1/α2fl/fl and AMPKα1/α2fl/flCre+ mice were probed for AMPKα protein abundance. n = 3. (E) Hepatic TAG levels. n = 5. (F) Assessment of hepatic lipid accumulation by Oil-Red...
葡萄糖法检测细胞的葡萄糖摄取:(2)培养L6细胞,分别给予AMPK抑制齐Compound C (1μmol/L作用30min)和Ca2+/钙调蛋白依赖性蛋白激酶激酶p (CaMKKβ)选择性抑制(... 刘坚 - 《武汉大学》 被引量: 0发表: 2012年 桑黄多糖P1对肝癌...
Moreover, cellular Ca2+ overload, the over-expression of CaMKK2, and the loss of mitochondria-associated membranes (MAM) were also relieved after 4-PBA co-treatment. Collectively, our data emphasized that ER stress plays critical role in 3-MCPD-mediated mitochondrial dysfunction and subsequent ...
Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK. Atherosclerosis 2008;200:28–36. Article CAS PubMed Google Scholar Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, et al. Ca2+/calmodulin-dependent protein kinase kinase-beta...