在该通路中,细胞核内复制压力下产生的DNA片段进入胞浆,通过非经典的cGAS-cGAMP-STING 信号传导过程,内质网上的TRPV2被激活,Ca2+得以释放到胞浆中,从而激活下游CaMKK2/AMPK/EXO1 信号轴,达到保护复制叉和基因组的作用。在后续的工作...
CaMKK2/AMPKOxidative stressTelbivudine (LdT), a widely prescribed anti-hepatitis B virus (HBV) drug for the treatment of chronic Hepatitis B (CHB), causes adverse reactions ranging from creatine kinase (CK) elevation to myopathy. The purpose of this study was to explore the mechanism(s) of ...
Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CAMKK2) acts as a signaling hub, receiving signals from various regulatory pathways and decoding them via phosphorylation of downstream protein kinases - such as AMPK (AMP-activated protein kinase) and CAMK types I and IV. CAMKK2 relevance is...
细胞内溶酶体上的Ca2+通道蛋白打开,Ca2+从溶酶体内流入细胞溶胶,细胞质中的Ca2+浓度升高,激活钙调磷酸酶,钙调磷酸酶催化TFEB-P去磷酸化形成TFEB,TFEB进入细胞核进而促进Atg基因表达,Atg8-PE增多促进自噬维持细胞(和生物体)生命活动;同时Ca2+既可以直接活化AMPK酶,也可以通过先活化CaMKKβ继而激活AMPK,活化的AMPK...
Moreover, cellular Ca2+ overload, the over-expression of CaMKK2, and the loss of mitochondria-associated membranes (MAM) were also relieved after 4-PBA co-treatment. Collectively, our data emphasized that ER stress plays critical role in 3-MCPD-mediated mitochondrial dysfunction and subsequent ...
(C) Immunoblot analysis for phospho and total CaMKK-II. n = 6. (D) Hepatocyte lysates from AMPKα1/α2fl/fl and AMPKα1/α2fl/flCre+ mice were probed for AMPKα protein abundance. n = 3. (E) Hepatic TAG levels. n = 5. (F) Assessment of hepatic lipid accumulation by Oil-Red...
Figure 2. Ca2+ signaling pathways in β-cells. Following Ca2+ binding to Calmodulin (CaM), multiple downstream pathways are activated. CaM activates the Ca2+/Calmodulin-dependent protein kinase kinase (CaMKK) as well as members of the Ca2+/Calmodulin-dependent protein kinases (CaMK). Ca2+/CaM...
Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway Article Open access 30 July 2021 TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate...
Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK. Atherosclerosis 2008;200:28–36. Article CAS PubMed Google Scholar Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, et al. Ca2+/calmodulin-dependent protein kinase kinase-beta...
n = 30-75 cells from 2-4 experiments. (B) The CaM Kinase Kinase (CaMKK) inhibitor, Sto-609 (3 μM), blocked both CaV1- and CaV2-mediated signaling. n > 45 cells from 3 experiments. (C) To test for the involvement of CaM Kinase family members, we looked for a combination of ...