cell Biol,1988,8(3):963～973. [10]Collins S.Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line[J].Nature,1982,298:679～681. [11]Gopal V,Hulette B,Li Yaqin,et al.C-myc and C-myb expression in acute myelogenous leukemia[J].Leuk Res,1992,16(...
Amino Acid Sequence Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu 一般描述 c-Myc 肽是一种合成肽,其氨基酸序列相当于人 c-Myc c 末端 410-419 位氨基酸。 包装 4, 25 mg in glass bottle 应用 用于在免疫测定中置换与抗 c-Myc 抗体结合的 c-Myc 标记融合蛋白。通过 c-Myc 肽成功抑制抗体结合,证明结...
C-Myc过表达在MM的发生和发展中起着关键的作用,目前认为MM中C-Myc过表达的机制有以5种:(1)染色体易位。涉及C-Myc异常表达的染色体易位情况在新诊断的MM患者中占20%～50%,这些易位涉及免疫球蛋白(immunoglobulin,Ig)基因位点和一些非Ig融合伴侣基因,如46序...
Comparative hybridization experiments revealed that the above procedure separates the c-myc sequences between the two fractions To locate the site of intranuclear c-myc transcription, we performed run-on experiments with two fractions, topologically analogous to the residual P and S fractions but ...
Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. Subunit: Efficient DNA binding requires dimerization with another bHLH protein....
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. 蛋白标签: N-terminal 6xHis-SUMO-tagged 产品提供形式: Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you ...
[0070]可以将具有编码Sox2、Klf4和任选的c‑Myc的多顺反子表达盒的游离型质粒载体引入到哺乳动物细胞中,如例如在以下中所述: Yu et al., Human induced pluripotent stem cells free of vector and transgene sequences, Science 324(5928): 797‑801(2009);美国专利申请20120076762,和Okita et al., A mor...
apoptosis and cellular transformation.The encoded protein forms a heterodimer with the related transcription factor MAX.This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes.Amplification of this gene is frequently observed in numerous human ...
This allows for the study of NF-kB dimers which bind to specific endogenous DNA sequences. How should I prepare my nuclear extract? Any of the following are compatible. Active Motif’s Nuclear Extract Kit (Cat. No. 40010/40410)** Preparation of Nuclear Extract protocol in the Appendix of ...
CAFs produce fibroblast growth factor 2 (FGF2), followed up with activation and recruition of ERα and PRBΔ4 to the MYC regulatory sequence leading to the breast cancer growth [48]. In breast cancer cells, TCF12 stimulates the activation of c-MYC/Cyclin D1 pathway to accelerate cancer ...