The feline and human sequences are colinear within the open reading frame from the putative c- myc product but show insertions and deletions relative to each other outside this domain. We have also analyzed a cloned FeLV provirus, CT4, which contains the host-derived myc gene. In this ...
cell Biol,1988,8(3):963～973. [10]Collins S.Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line[J].Nature,1982,298:679～681. [11]Gopal V,Hulette B,Li Yaqin,et al.C-myc and C-myb expression in acute myelogenous leukemia[J].Leuk Res,1992,16(...
Amino Acid Sequence Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu 一般描述 c-Myc 肽是一种合成肽,其氨基酸序列相当于人 c-Myc c 末端 410-419 位氨基酸。 包装 4, 25 mg in glass bottle 应用 用于在免疫测定中置换与抗 c-Myc 抗体结合的 c-Myc 标记融合蛋白。通过 c-Myc 肽成功抑制抗体结合,证明结...
C-Myc过表达在MM的发生和发展中起着关键的作用,目前认为MM中C-Myc过表达的机制有以5种:(1)染色体易位。涉及C-Myc异常表达的染色体易位情况在新诊断的MM患者中占20%～50%,这些易位涉及免疫球蛋白(immunoglobulin,Ig)基因位点和一些非Ig融合伴侣基因,如46序...
c-MYC peptide fragments detected by LC-MS/MS. 23 specific peptides corresponding to 51% of the c-MYC sequence were detected in the control sample. Ten specific peptides corresponding to 23% of the sequence were found after recombinant Lon protease (rLon) degradation of c-MYC.d, Binding of...
RUNNINGTITLE:THEC-MYCQUADRUPLEXSEQUENCEINDUCESCELLDEATH Addresscorrespondenceto:DonaldM.Miller,JamesGrahamBrownCancerCenter,University ofLouisville,529SouthJacksonSt.,Louisville,Kentucky40202,Tel:(502)562-4585;Fax. (502)562-4368;Email:donaldmi@ulh
While it has been known for some time that the c-Myc protein binds to random DNA sequences, no sequence-specific binding activity has been detected. At its carboxyl terminus, c-Myc contains a basic-helix-loop-helix (bHLH) motif, which is important for dimerization and specific DNA binding,...
Express target protein with C-terminal Myc tag in mammalian cell •Depositor Beyotime •Publication Song et al. ONCOTARGET. 2017Feb 7;8(6):9108-9122. •Sequence Information D2672 pCMV-C-Myc-seq.txt For Details Add to cart Brief Information Name Catalog No. Size Description pCMV-C-Myc...
图1c-Myc结构 [2] MB:Myc盒;TAD:转录激活域;NLS:核定位序列;HLH:螺旋-环-螺旋结构;Zip:拉链结构。 研究中发现c-Myc对基因的转录抑制作用还需要甲 基化酶对该基因启动子区进行DNA甲基化 [9] 。 下降 [14] 。 c-Myc的过表达会导致细胞周期蛋白A、细胞 周期蛋白E以及细胞周期蛋白D2的表达上升,其中 c-...
The c-Myc sequence was amplified using NB4 cDNA and then cloned into the pcDNA3.1 (+) vector. Detailed primer information is listed in Table S2. Transient transfection and luciferase reporter assay NB4 cells were electro-transfected using the Amaxa Nucleofector II device (Lonza, Cologne, Germany)...