C-Myc过表达在MM的发生和发展中起着关键的作用,目前认为MM中C-Myc过表达的机制有以5种:(1)染色体易位。涉及C-Myc异常表达的染色体易位情况在新诊断的MM患者中占20%～50%,这些易位涉及免疫球蛋白(immunoglobulin,Ig)基因位点和一些非Ig融合伴侣基因,如46序...
RUNNINGTITLE:THEC-MYCQUADRUPLEXSEQUENCEINDUCESCELLDEATH Addresscorrespondenceto:DonaldM.Miller,JamesGrahamBrownCancerCenter,University ofLouisville,529SouthJacksonSt.,Louisville,Kentucky40202,Tel:(502)562-4585;Fax. (502)562-4368;Email:donaldmi@ulh
Express target protein with C-terminal Myc tag in mammalian cell •Depositor Beyotime •Publication Song et al. ONCOTARGET. 2017Feb 7;8(6):9108-9122. •Sequence Information D2672 pCMV-C-Myc-seq.txt For Details Add to cart Brief Information Name Catalog No. Size Description pCMV-C-Myc...
Amino Acid Sequence Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu 一般描述 c-Myc 肽是一种合成肽,其氨基酸序列相当于人 c-Myc c 末端 410-419 位氨基酸。 包装 4, 25 mg in glass bottle 应用 用于在免疫测定中置换与抗 c-Myc 抗体结合的 c-Myc 标记融合蛋白。通过 c-Myc 肽成功抑制抗体结合,证明结...
Sequence Analysis, DNAPrecipitin TestsCpG IslandsE-Box ElementsThe transcription factor Myc is induced by mitogenic signals and regulates downstream cellular responses. If overexpressed, Myc promotes malignant transformation. Myc modulates expression of diverse genes in experimental systems, but few are ...
genes through binding the consensus sequence E box within the promoter region, it can also positively or negatively regulate other target genes. c-Myc participates the regulation of cell proliferation, differentiation, growth, apoptosis, cell cycle progression, cellular immortalization and oncogenic transfo...
5′-AGCGUGUAGCUAGCAGAGG-3′ was used as negative control sequence. Retroviral construct and transfection The sequence encoding full-length MAP3K1 was amplified from cDNA of NB4 cells and then directionally cloned into retroviral vector MigR1, by Xho I and EcoR I sites, to form plasmid MigR1...
sequence. Western blot analysis and immunohistochemistry showed that KDM2B was overexpressed in HPV16 E6/E7-positive keratinocytes, in cervical cancer cell lines, and in a subset of invasive cervical carcinomas and HPV-p...
c-MYC peptide fragments detected by LC-MS/MS. 23 specific peptides corresponding to 51% of the c-MYC sequence were detected in the control sample. Ten specific peptides corresponding to 23% of the sequence were found after recombinant Lon protease (rLon) degradation of c-MYC.d, Binding of...
KLH-conjugated peptide, amino acids 408-420 ( sequence MEQKLISEEDLNE), of the C-terminal domian of human c-Myc P01106. antibody format hen polyclonal affinity purified IgY PBS pH 8.5 + 0.004 % sodium azide lyophilized quantity 100 µg - for reconstitution add 100 µl of sterile water...