p53 直接激活其转录靶标p21,从而稳定转录调节因子 Nrf2并增强其活性,发挥一系列的抗氧化基因激活功能[130]。 1.4.7 AMPK AMP 活化蛋白激酶 (AMPK)是一种异源的丝氨酸/苏氨酸蛋白激酶三聚体复合物[131],由一个催化性 α-亚基(α1 和α2,分别由基因PRKAA1和PRKAA2编码、一个支架 β-亚基(β1 和β2,分别...
在HNF4α-KO条件下,cMyc被诱导,进而抑制Nrf2,导致更高程度的肝损伤。而在HNF4α-KO中抑制cMyc,即在DKO小鼠中,Nrf2激活恢复,导致GSH快速补充,肝损伤减轻。 图7 APAP造模后DKO小鼠谷胱甘肽补充加快 综上所述,本研究揭示了APAP过量...
目的:探讨小细胞肺癌c-myc癌基因的表达对Nrf2表达的影响,分析c-myc与 Nrf2表达的相关性.方法:选用两株耐药性不同的肺小细胞癌肿瘤细胞株,小细胞肺癌药物敏感株H69及耐药株H69AR,Westem-B10t方法比 较Nrf2,c-myc在两株细胞间的表达差异;H69细胞通过Lipofectamine2000脂质体转染过表达c-myc,Western- Blot方法...
目的评价沉默信息调节因子1/核因子E2相关因子2(SIRT1/Nrf2)信号通路在小檗碱预处理减轻小鼠肠缺血再灌注损伤中的作用及其与铁死亡的关系.方法SPF级健康雄性C57BL/6小... 高焕焕,冷玉芳,王心润,... - 《中华麻醉学杂志》 被引量: 0发表: 2023年
另外,紫檀芪(20μmol/L)显著上调氧化应激MC3T3-E1中c-myc和Nrf2的蛋白表达量(**P<0.01).干扰c-myc表达可有效抑制紫檀芪对氧化应激MC3T3-E1的Nrf2蛋白表达量(**P<0.01),细胞活力(**P<0.01),LDH漏出量(**P<0.01),caspase-3活性(**P<0.01)和ROS水平(**P<0.01)的作用.结论 紫檀芪可通过c-myc调控Nrf2表达...
(LCA) has been found to mediate the c-Myc overexpression, which activates the transcription of miR27a/b and reduce the expression of PHB1 andNrf2. Knockdown of c-Myc or miR27a/b has showed protective effects in liver against LCA-induced oxidative stress. Furthermore, miR-27 has been ...
Fig. 6: Induction ofmiR-34a/b/cby salicylate is mediated by NRF2. mRNA (A,B) and protein (C) levels of NRF2 and NQO1 were determined by qPCR and Western blot analysis, respectively.DImmunofluorescence was used to detect the location of NRF2 protein after the indicated treatments for 48...
C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements. IUBMB Life. 2010;62:237–46. Article CAS Google Scholar Feng XH, Liang YY, Liang M, Zhai W, Lin X. Direct interaction of c-Myc with Smad2 and Smad3 to inhibit ...
名称:NF-E2相关因子2/抗氧化反应元件(Nrf2/ARE)激活剂(CDDO-EA) 货号:M00796 规格:1mL(10mM)|2mg|5mg|10mg|50mg|100mg CDDO-EA是一种NF-E2相关因子2/抗氧化反应元件(Nrf2/ARE)激活剂。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途! CAS号:932730-51-3 别名:CDDO ethyl amide;TP319;RTA 405...
https://doi.org/10.1016/j.ajpath.2024.03.008Get rights and content Under a Creative Commons license open accessHepatocyte nuclear factor 4 alpha (HNF4α) is a nuclear factor essential for liver function that regulates the expression of cMyc and plays an important role during liver regeneration....